Tbc1d13 TBC1 domain family, member 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tbc1d13provided by RGD
Official Full Name: TBC1 domain family, member 13provided by RGD
Primary source: RGD:1591937
See related: Ensembl:ENSRNOG00000015970 AllianceGenome:RGD:1591937
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in cytosol and membrane. Orthologous to human TBC1D13 (TBC1 domain family member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 198.8), Thymus (RPKM 67.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (33806772..33823346)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (13408944..13425524)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (8701849..8718400)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

MARC_27502-27503:1034792889:3 (e-PCR)
- UniSTS:269105

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of cilium assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TBC1 domain family member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399454.1 → NP_001386383.1 TBC1 domain family member 13

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

D4AEG7

Related

ENSRNOP00000021431.6, ENSRNOT00000021431.8

Conserved Domains (1) summary

smart00164
Location:32 → 367

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

33806772..33823346

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284345.1 → XP_063140415.1 TBC1 domain family member 13 isoform X3
XM_039106775.2 → XP_038962703.1 TBC1 domain family member 13 isoform X1

Conserved Domains (1) summary

smart00164
Location:28 → 291

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
XM_039106776.2 → XP_038962704.1 TBC1 domain family member 13 isoform X2

Conserved Domains (1) summary

cl02495
Location:28 → 186

RabGAP-TBC; Rab-GTPase-TBC domain