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    Ces2h carboxylesterase 2H [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498940, updated on 29-Feb-2024

    Summary

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    Official Symbol
    Ces2hprovided by RGD
    Official Full Name
    carboxylesterase 2Hprovided by RGD
    Primary source
    RGD:1560889
    See related
    Ensembl:ENSRNOG00000039079 AllianceGenome:RGD:1560889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ces2
    Summary
    Predicted to enable carboxylic ester hydrolase activity. Involved in response to organic substance. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human CES2 (carboxylesterase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 184.7) and Kidney (RPKM 137.4) See more
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    Genomic context

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    See Ces2h in Genome Data Viewer
    Location:
    19q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (49884164..49898764)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (32974242..32988842)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37052555..37067176)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene carboxylesterase 2G Neighboring gene acylcarnitine hydrolase-like Neighboring gene carboxylesterase 3a Neighboring gene carboxylesterase 4A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene expression profiling in liver and testis of rats to characterize the toxicity of triazole fungicides. Tully DB, et al. Toxicol Appl Pharmacol, 2006 Sep 15. PMID 16643972
    2. Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2. Xie S, et al. Chem Res Toxicol, 2010 Dec 20. PMID 21049984, Free PMC Article
    3. Different inhibitory effects in rat and human carboxylesterases. Takahashi S, et al. Drug Metab Dispos, 2009 May. PMID 19225040
    4. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxylesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to organic substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carboxylesterase 2
    Names
    carboxylesterase 2 (intestine, liver)
    NP_001037723.1
    NP_001177275.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044258.2 → NP_001037723.1  carboxylesterase 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001037723.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC088223, BC107806
      UniProtKB/TrEMBL
      M0R8J8, Q32Q55
      Related
      ENSRNOP00000019072.5, ENSRNOT00000019072.8
      Conserved Domains (2) summary
      COG0657
      Location:127 → 230
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:30 → 537
      COesterase; Carboxylesterase family

    2. NM_001190346.1 → NP_001177275.1  carboxylesterase 2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice junction in the 3' CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      BC088223, BC107806
      UniProtKB/TrEMBL
      Q32Q55
      Conserved Domains (2) summary
      COG0657
      Location:127 → 230
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:30 → 438
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      49884164..49898764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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