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    Plcz1 phospholipase C, zeta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497197, updated on 13-Apr-2024

    Summary

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    Symbol
    Plcz1provided by RGD
    Full Name
    phospholipase C, zeta 1provided by RGD
    Primary source
    RGD:1359567
    See related
    Ensembl:ENSRNOG00000008514 AllianceGenome:RGD:1359567
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity and phosphatidylinositol phospholipase C activity. Involved in positive regulation of cytosolic calcium ion concentration involved in egg activation. Located in cytoplasm. Human ortholog(s) of this gene implicated in spermatogenic failure 17. Orthologous to human PLCZ1 (phospholipase C zeta 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 270.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q44
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (174604281..174660368, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (172873110..172929191, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (174125072..174181524, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RERG like Neighboring gene uncharacterized LOC120102423 Neighboring gene phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma Neighboring gene capping actin protein of muscle Z-line subunit alpha 3 Neighboring gene uncharacterized LOC108350783

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ. Nomikos M, et al. Biochem J, 2017 Mar 7. PMID 28270562
    2. Recombinant phospholipase Czeta has high Ca2+ sensitivity and induces Ca2+ oscillations in mouse eggs. Kouchi Z, et al. J Biol Chem, 2004 Mar 12. PMID 14701816
    3. PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development. Saunders CM, et al. Development, 2002 Aug. PMID 12117804
    4. Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP. Escoffier J, et al. Hum Mol Genet, 2016 Mar 1. PMID 26721930, Free PMC Article
    5. Difference in Ca2+ oscillation-inducing activity and nuclear translocation ability of PLCZ1, an egg-activating sperm factor candidate, between mouse, rat, human, and medaka fish. Ito M, et al. Biol Reprod, 2008 Jun. PMID 18322275

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. All PLCZ1 proteins including fish could induce Ca(2+) oscillations in mouse eggs, but the activity was variable in the order of human >> mouse > medaka >> rat, estimated from minimal RNA concentration to induce Ca(2+) spikes.
      Title: Difference in Ca2+ oscillation-inducing activity and nuclear translocation ability of PLCZ1, an egg-activating sperm factor candidate, between mouse, rat, human, and medaka fish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-5-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within egg activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in egg activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in egg activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration involved in egg activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration involved in egg activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration involved in egg activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pronucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm head ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
    Names
    PLC-zeta-1
    phosphoinositide phospholipase C-zeta-1
    NP_001012234.1
    XP_006237662.1
    XP_017448260.1
    XP_038963974.1
    XP_038963975.1
    XP_038963976.1
    XP_038963978.1
    XP_038963979.1
    XP_038963980.1
    XP_063142523.1
    XP_063142524.1
    XP_063142525.1
    XP_063142526.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012234.2 → NP_001012234.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

      See identical proteins and their annotated locations for NP_001012234.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q5FX52
      UniProtKB/TrEMBL
      A6IMM6
      Related
      ENSRNOP00000011376.4, ENSRNOT00000011376.5
      Conserved Domains (2) summary
      PLN02952
      Location:78 → 640
      PLN02952; phosphoinositide phospholipase C
      cl14615
      Location:161 → 488
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      174604281..174660368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286453.1 → XP_063142523.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1

      UniProtKB/Swiss-Prot
      Q5FX52
      UniProtKB/TrEMBL
      A6IMM6

    2. XM_063286454.1 → XP_063142524.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1

      UniProtKB/Swiss-Prot
      Q5FX52
      UniProtKB/TrEMBL
      A6IMM6

    3. XM_063286456.1 → XP_063142526.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X4

    4. XM_039108048.2 → XP_038963976.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

      Conserved Domains (2) summary
      PLN02230
      Location:1 → 529
      PLN02230; phosphoinositide phospholipase C 4
      cl14615
      Location:52 → 379
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    5. XM_039108050.2 → XP_038963978.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

      Conserved Domains (2) summary
      PLN02230
      Location:1 → 529
      PLN02230; phosphoinositide phospholipase C 4
      cl14615
      Location:52 → 379
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    6. XM_006237600.5 → XP_006237662.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X2

      Conserved Domains (4) summary
      cd00275
      Location:494 → 619
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      PLN02952
      Location:54 → 616
      PLN02952; phosphoinositide phospholipase C
      pfam09279
      Location:55 → 137
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl14615
      Location:137 → 464
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    7. XM_039108047.2 → XP_038963975.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

      Conserved Domains (2) summary
      PLN02230
      Location:1 → 529
      PLN02230; phosphoinositide phospholipase C 4
      cl14615
      Location:52 → 379
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    8. XM_063286455.1 → XP_063142525.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

    9. XM_039108051.2 → XP_038963979.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X4

      Conserved Domains (2) summary
      PLN02952
      Location:23 → 417
      PLN02952; phosphoinositide phospholipase C
      cl14615
      Location:23 → 265
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    10. XM_039108046.2 → XP_038963974.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

      Conserved Domains (2) summary
      PLN02230
      Location:1 → 529
      PLN02230; phosphoinositide phospholipase C 4
      cl14615
      Location:52 → 379
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    11. XM_017592771.3 → XP_017448260.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X2

      Conserved Domains (4) summary
      cd00275
      Location:494 → 619
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      PLN02952
      Location:54 → 616
      PLN02952; phosphoinositide phospholipase C
      pfam09279
      Location:55 → 137
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl14615
      Location:137 → 464
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    12. XM_039108052.2 → XP_038963980.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X5

      Conserved Domains (2) summary
      cd00275
      Location:252 → 377
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cl14615
      Location:1 → 222
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    RNA

    1. XR_010065686.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FX52.1 GenPept UniProtKB/Swiss-Prot:Q5FX52

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