MEP1B meprin A subunit beta [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: MEP1Bprovided by VGNC
Official Full Name: meprin A subunit betaprovided by VGNC
Primary source: VGNC:VGNC:43160
See related: Ensembl:ENSCAFG00845009736
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 7

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	7	NC_051811.1 (57436320..57459609, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	7	NC_006589.4 (56888238..56911333, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	7	NC_049228.1 (57429048..57452158, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	7	NC_049267.1 (57114830..57136681, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	7	NC_049748.1 (57132324..57155413, complement)

Chromosome 7 - NC_051811.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: meprin A subunit beta; LOW QUALITY PROTEIN: meprin A subunit beta

XP_005623043.2

EC 3.4.24.18

XP_038338564.1

EC 3.4.24.18

XP_038397715.1

EC 3.4.24.18

XP_038397716.1

EC 3.4.24.18

XP_038436849.1

EC 3.4.24.18

XP_038461840.1

EC 3.4.24.18

XP_038461841.1

EC 3.4.24.18

XP_038526550.1

EC 3.4.24.18

XP_038526551.1

EC 3.4.24.18

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051811.1 Reference ROS_Cfam_1.0

Range

57436320..57459609 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038670622.1 → XP_038526550.1 meprin A subunit beta isoform X1

UniProtKB/TrEMBL

A0A8C0RAE6, A0A8I3N8N6, A0A8P0NJA5

Related

ENSCAFP00845013378.1, ENSCAFT00845017171.1

Conserved Domains (3) summary

smart00137
Location:262 → 429

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd04282
Location:30 → 257

ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...

cl02446
Location:429 → 588

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
XM_038670623.1 → XP_038526551.1 meprin A subunit beta isoform X2

UniProtKB/TrEMBL

A0A8C0RAE6, A0A8I3NBN2, A0A8P0NUB0

Related

ENSCAFP00845013448.1, ENSCAFT00845017257.1

Conserved Domains (3) summary

smart00137
Location:262 → 429

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd04282
Location:30 → 257

ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...

cl02446
Location:429 → 588

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049267.1 Alternate UMICH_Zoey_3.1

Range

57114830..57136681 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038482636.1 → XP_038338564.1 LOW QUALITY PROTEIN: meprin A subunit beta isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049748.1 Alternate UNSW_CanFamBas_1.0

Range

57132324..57155413 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038605912.1 → XP_038461840.1 meprin A subunit beta isoform X1

Conserved Domains (3) summary

smart00137
Location:262 → 429

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd04282
Location:30 → 257

ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...

cl02446
Location:429 → 588

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
XM_038605913.1 → XP_038461841.1 meprin A subunit beta isoform X2

Conserved Domains (3) summary

smart00137
Location:262 → 429

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd04282
Location:30 → 257

ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...

cl02446
Location:429 → 588

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049228.1 Alternate UU_Cfam_GSD_1.0

Range

57429048..57452158 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038541787.1 → XP_038397715.1 meprin A subunit beta isoform X1

UniProtKB/TrEMBL

A0A8C0RAE6, A0A8I3N8N6, A0A8P0NJA5

Conserved Domains (3) summary

smart00137
Location:262 → 429

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd04282
Location:30 → 257

ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...

cl02446
Location:429 → 588

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
XM_038541788.1 → XP_038397716.1 meprin A subunit beta isoform X2

UniProtKB/TrEMBL

A0A8C0RAE6, A0A8I3NBN2, A0A8P0NUB0

Conserved Domains (3) summary

smart00137
Location:262 → 429

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd04282
Location:30 → 257

ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...

cl02446
Location:429 → 588

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

56888238..56911333 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005622986.3 → XP_005623043.2 meprin A subunit beta isoform X1

UniProtKB/TrEMBL

A0A8C0RAE6, A0A8I3N8N6, A0A8P0NJA5

Conserved Domains (3) summary

smart00137
Location:262 → 429

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd04282
Location:30 → 257

ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...

cl02446
Location:429 → 588

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
XM_038580921.1 → XP_038436849.1 meprin A subunit beta isoform X2

UniProtKB/TrEMBL

A0A8C0RAE6, A0A8I3NBN2, A0A8P0NUB0

Conserved Domains (3) summary

smart00137
Location:262 → 429

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd04282
Location:30 → 257

ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...

cl02446
Location:429 → 588

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...