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    NPL N-acetylneuraminate pyruvate lyase [ Canis lupus familiaris (dog) ]

    Gene ID: 490313, updated on 5-Mar-2024

    Summary

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    Official Symbol
    NPLprovided by VGNC
    Official Full Name
    N-acetylneuraminate pyruvate lyaseprovided by VGNC
    Primary source
    VGNC:VGNC:43921
    See related
    Ensembl:ENSCAFG00845004288
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 7
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (15916535..15955524)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (15773528..15812293)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (16066339..16105552)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (15828310..15866959)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (15937498..15975727)

    Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102155735 Neighboring gene regulator of G protein signaling 8 Neighboring gene uncharacterized LOC119872509 Neighboring gene DExH-box helicase 9 Neighboring gene SHC binding and spindle associated 1 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 4-hydroxy-tetrahydrodipicolinate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables N-acetylneuraminate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-acetylneuraminate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acetylneuraminate lyase
    XP_038336833.1
    XP_038336834.1
    XP_038336835.1
    XP_038398177.1
    XP_038398178.1
    XP_038398179.1
    XP_038420127.1
    XP_038420136.1
    XP_038420143.1
    XP_038462341.1
    XP_038462342.1
    XP_038462343.1
    XP_038527009.1
    XP_038527010.1
    XP_038527011.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051811.1 Reference ROS_Cfam_1.0

      Range
      15916535..15955524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038671081.1 → XP_038527009.1  N-acetylneuraminate lyase isoform X1

      UniProtKB/TrEMBL
      A0A8C0KPU4, A0A8C0PUC6, A0A8I3MMG3, A0A8I3MW42, A0A8P0TU20
      Related
      ENSCAFP00845006121.1, ENSCAFT00845007732.1
      Conserved Domains (1) summary
      cd00954
      Location:8 → 306
      NAL; N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL)

    2. XM_038671082.1 → XP_038527010.1  N-acetylneuraminate lyase isoform X2

      Conserved Domains (1) summary
      cl21457
      Location:8 → 246
      TIM; TIM-like beta/alpha barrel domains

    3. XM_038671083.1 → XP_038527011.1  N-acetylneuraminate lyase isoform X3

      UniProtKB/TrEMBL
      A0A8C0M798, A0A8C0MC35, A0A8I3MRX6, A0A8I3MUD2
      Related
      ENSCAFP00845006128.1, ENSCAFT00845007739.1
      Conserved Domains (1) summary
      cl21457
      Location:8 → 218
      TIM; TIM-like beta/alpha barrel domains

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049267.1 Alternate UMICH_Zoey_3.1

      Range
      15828310..15866959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038480905.1 → XP_038336833.1  N-acetylneuraminate lyase isoform X1

      Conserved Domains (1) summary
      cd00954
      Location:8 → 306
      NAL; N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL)

    2. XM_038480906.1 → XP_038336834.1  N-acetylneuraminate lyase isoform X2

      Conserved Domains (1) summary
      cl21457
      Location:8 → 246
      TIM; TIM-like beta/alpha barrel domains

    3. XM_038480907.1 → XP_038336835.1  N-acetylneuraminate lyase isoform X3

      Conserved Domains (1) summary
      cl21457
      Location:8 → 218
      TIM; TIM-like beta/alpha barrel domains

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

      Range
      15937498..15975727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038606413.1 → XP_038462341.1  N-acetylneuraminate lyase isoform X1

      Conserved Domains (1) summary
      cd00954
      Location:8 → 306
      NAL; N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL)

    2. XM_038606414.1 → XP_038462342.1  N-acetylneuraminate lyase isoform X2

      Conserved Domains (1) summary
      cl21457
      Location:8 → 246
      TIM; TIM-like beta/alpha barrel domains

    3. XM_038606415.1 → XP_038462343.1  N-acetylneuraminate lyase isoform X3

      Conserved Domains (1) summary
      cl21457
      Location:8 → 218
      TIM; TIM-like beta/alpha barrel domains

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

      Range
      16066339..16105552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038542249.1 → XP_038398177.1  N-acetylneuraminate lyase isoform X1

      UniProtKB/TrEMBL
      A0A8C0KPU4, A0A8C0PUC6, A0A8I3MMG3, A0A8I3MW42, A0A8P0TU20
      Conserved Domains (1) summary
      cd00954
      Location:8 → 306
      NAL; N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL)

    2. XM_038542250.1 → XP_038398178.1  N-acetylneuraminate lyase isoform X2

      Conserved Domains (1) summary
      cl21457
      Location:8 → 246
      TIM; TIM-like beta/alpha barrel domains

    3. XM_038542251.1 → XP_038398179.1  N-acetylneuraminate lyase isoform X3

      UniProtKB/TrEMBL
      A0A8C0M798, A0A8C0MC35, A0A8I3MRX6, A0A8I3MUD2
      Conserved Domains (1) summary
      cl21457
      Location:8 → 218
      TIM; TIM-like beta/alpha barrel domains

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      15773528..15812293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038564199.1 → XP_038420127.1  N-acetylneuraminate lyase isoform X1

      UniProtKB/TrEMBL
      A0A8C0KPU4, A0A8C0PUC6, A0A8I3MMG3, A0A8I3MW42, A0A8P0TU20
      Conserved Domains (1) summary
      cd00954
      Location:8 → 306
      NAL; N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL)

    2. XM_038564208.1 → XP_038420136.1  N-acetylneuraminate lyase isoform X2

      Conserved Domains (1) summary
      cl21457
      Location:8 → 246
      TIM; TIM-like beta/alpha barrel domains

    3. XM_038564215.1 → XP_038420143.1  N-acetylneuraminate lyase isoform X3

      UniProtKB/TrEMBL
      A0A8C0M798, A0A8C0MC35, A0A8I3MRX6, A0A8I3MUD2
      Conserved Domains (1) summary
      cl21457
      Location:8 → 218
      TIM; TIM-like beta/alpha barrel domains
    Nucleotide Protein
    Heading Accession and Version

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