U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    KCNJ10 potassium inwardly rectifying channel subfamily J member 10 [ Canis lupus familiaris (dog) ]

    Gene ID: 488635, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    KCNJ10provided by VGNC
    Official Full Name
    potassium inwardly rectifying channel subfamily J member 10provided by VGNC
    Primary source
    VGNC:VGNC:110595
    See related
    Ensembl:ENSCAFG00845030876
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 38
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 38 NC_051842.1 (22234321..22263231)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 38 NC_006620.4 (22189839..22218736)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 38 NC_049259.1 (22944114..22972999)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 38 NC_049298.1 (22138483..22167351)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 38 NC_049779.1 (22534821..22563698)

    Chromosome 38 - NC_051842.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily member 8 Neighboring gene uncharacterized LOC111094550 Neighboring gene potassium inwardly rectifying channel subfamily J member 9 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class M Neighboring gene SLAM family member 9

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A Missense Variant in KCNJ10 in Belgian Shepherd Dogs Affected by Spongy Degeneration with Cerebellar Ataxia (SDCA1). Mauri N, et al. G3 (Bethesda), 2017 Feb 9. PMID 28007838, Free PMC Article
    2. The novel homozygous KCNJ10 c.986T>C (p.(Leu329Pro)) variant is pathogenic for the SeSAME/EAST homologue in Malinois dogs. Van Poucke M, et al. Eur J Hum Genet, 2017 Feb. PMID 27966545, Free PMC Article
    3. A KCNJ10 mutation previously identified in the Russell group of terriers also occurs in Smooth-Haired Fox Terriers with hereditary ataxia and in related breeds. Rohdin C, et al. Acta Vet Scand, 2015 May 23. PMID 25998802, Free PMC Article
    4. Regulation of Kir4.1 and AQP4 expression and stability at the basolateral domain of epithelial MDCK cells by the extracellular matrix. Tham DK, et al. Am J Physiol Renal Physiol, 2011 Aug. PMID 21543416, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we consider KCNJ10:c.986T>C the most likely candidate causative variant for one subtype of SDCA in Malinois dogs, which we propose to term spongy degeneration with cerebellar ataxia 1 (SDCA1).
      Title: A Missense Variant in KCNJ10 in Belgian Shepherd Dogs Affected by Spongy Degeneration with Cerebellar Ataxia (SDCA1).
    2. A novel pathogenic KCNJ10 c.986T>C (p.(Leu329Pro)) variant identified in dogs with SeSAME/EAST syndrome.
      Title: The novel homozygous KCNJ10 c.986T>C (p.(Leu329Pro)) variant is pathogenic for the SeSAME/EAST homologue in Malinois dogs.
    3. A KCNJ10 mutation, previously associated with an autosomal recessive spinocerebellar ataxia in Jack Russell Terriers, Parson Russell Terriers, and Russell Terriers segregates in at least three more breeds descended from British hunting terriers.
      Title: A KCNJ10 mutation previously identified in the Russell group of terriers also occurs in Smooth-Haired Fox Terriers with hereditary ataxia and in related breeds.
    4. interaction of dystroglycan and integrins with the extracellular matrix plays an important role in the polarized distribution of Kir4.1 and AQP4 at the basolateral domain of kidney epithelial cells
      Title: Regulation of Kir4.1 and AQP4 expression and stability at the basolateral domain of epithelial MDCK cells by the extracellular matrix.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables inward rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in potassium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ATP-sensitive inward rectifier potassium channel 10
    Names
    potassium channel inwardly rectifying subfamily J member 10
    potassium voltage-gated channel subfamily J member 10

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051842.1 Reference ROS_Cfam_1.0

      Range
      22234321..22263231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038448704.1 → XP_038304632.1  ATP-sensitive inward rectifier potassium channel 10 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NBG7, A0A8C0SYI0, A0A8I3Q5M6
      Related
      ENSCAFP00845043159.1, ENSCAFT00845054881.1
      Conserved Domains (2) summary
      pfam01007
      Location:66 → 207
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:214 → 389
      IRK_C; Inward rectifier potassium channel C-terminal domain

    2. XM_038448705.1 → XP_038304633.1  ATP-sensitive inward rectifier potassium channel 10 isoform X2

      UniProtKB/TrEMBL
      A0A1P8VFW1, A0A8C0NBG7
      Conserved Domains (2) summary
      pfam01007
      Location:31 → 172
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:179 → 354
      IRK_C; Inward rectifier potassium channel C-terminal domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049298.1 Alternate UMICH_Zoey_3.1

      Range
      22138483..22167351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038522585.1 → XP_038378513.1  ATP-sensitive inward rectifier potassium channel 10 isoform X1

      Conserved Domains (2) summary
      pfam01007
      Location:66 → 207
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:214 → 389
      IRK_C; Inward rectifier potassium channel C-terminal domain

    2. XM_038522586.1 → XP_038378514.1  ATP-sensitive inward rectifier potassium channel 10 isoform X2

      Conserved Domains (2) summary
      pfam01007
      Location:31 → 172
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:179 → 354
      IRK_C; Inward rectifier potassium channel C-terminal domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049779.1 Alternate UNSW_CanFamBas_1.0

      Range
      22534821..22563698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038650792.1 → XP_038506720.1  ATP-sensitive inward rectifier potassium channel 10 isoform X1

      Conserved Domains (2) summary
      pfam01007
      Location:66 → 207
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:214 → 389
      IRK_C; Inward rectifier potassium channel C-terminal domain

    2. XM_038650793.1 → XP_038506721.1  ATP-sensitive inward rectifier potassium channel 10 isoform X2

      Conserved Domains (2) summary
      pfam01007
      Location:31 → 172
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:179 → 354
      IRK_C; Inward rectifier potassium channel C-terminal domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049259.1 Alternate UU_Cfam_GSD_1.0

      Range
      22944114..22972999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038586373.1 → XP_038442301.1  ATP-sensitive inward rectifier potassium channel 10 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NBG7, A0A8C0SYI0, A0A8I3Q5M6
      Conserved Domains (2) summary
      pfam01007
      Location:66 → 207
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:214 → 389
      IRK_C; Inward rectifier potassium channel C-terminal domain

    2. XM_038586374.1 → XP_038442302.1  ATP-sensitive inward rectifier potassium channel 10 isoform X2

      UniProtKB/TrEMBL
      A0A1P8VFW1, A0A8C0NBG7
      Conserved Domains (2) summary
      pfam01007
      Location:31 → 172
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:179 → 354
      IRK_C; Inward rectifier potassium channel C-terminal domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006620.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      22189839..22218736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005640901.4 → XP_005640958.1  ATP-sensitive inward rectifier potassium channel 10 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NBG7, A0A8C0SYI0, A0A8I3Q5M6
      Conserved Domains (2) summary
      pfam01007
      Location:66 → 207
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:214 → 389
      IRK_C; Inward rectifier potassium channel C-terminal domain

    2. XM_545752.7 → XP_545752.3  ATP-sensitive inward rectifier potassium channel 10 isoform X2

      UniProtKB/TrEMBL
      A0A1P8VFW1, A0A8C0NBG7
      Conserved Domains (2) summary
      pfam01007
      Location:31 → 172
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:179 → 354
      IRK_C; Inward rectifier potassium channel C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.