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    TIAM1 TIAM Rac1 associated GEF 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 487731, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TIAM1provided by VGNC
    Official Full Name
    TIAM Rac1 associated GEF 1provided by VGNC
    Primary source
    VGNC:VGNC:56122
    See related
    Ensembl:ENSCAFG00845021944
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 31
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 31 NC_051835.1 (26177246..26558745, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 31 NC_006613.4 (26051519..26432492, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 31 NC_049252.1 (26641221..27022148, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 31 NC_049291.1 (26123696..26504723, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 31 NC_049772.1 (26135327..26516773, complement)

    Chromosome 31 - NC_051835.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111093556 Neighboring gene uncharacterized LOC119867051 Neighboring gene keratin associated protein 11-1 Neighboring gene uncharacterized LOC119867106 Neighboring gene U6 spliceosomal RNA Neighboring gene superoxide dismutase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions. Guillemot L, et al. Mol Biol Cell, 2008 Oct. PMID 18653465, Free PMC Article
    2. Par-3 controls tight junction assembly through the Rac exchange factor Tiam1. Chen X, et al. Nat Cell Biol, 2005 Mar. PMID 15723052

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions
      Title: Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions.
    2. Par-3 has a role in tight junction assembly through the Rac exchange factor Tiam1
      Title: Par-3 controls tight junction assembly through the Rac exchange factor Tiam1.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-lymphoma invasion and metastasis-inducing protein 1
    Names
    T cell lymphoma invasion and metastasis 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051835.1 Reference ROS_Cfam_1.0

      Range
      26177246..26558745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038443333.1 → XP_038299261.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
      Related
      ENSCAFP00845030801.1, ENSCAFT00845039314.1
      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    2. XM_038443334.1 → XP_038299262.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    3. XM_038443335.1 → XP_038299263.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    4. XM_038443332.1 → XP_038299260.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    5. XM_038443336.1 → XP_038299264.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X2

      Conserved Domains (6) summary
      smart00325
      Location:730 → 919
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:532 → 611
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:118 → 244
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:921 → 1092
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:452 → 521
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:258 → 355
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    6. XM_038443337.1 → XP_038299265.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0N581, A0A8C0R8A0, A0A8I3PFD3
      Related
      ENSCAFP00845031192.1, ENSCAFT00845039828.1
      Conserved Domains (2) summary
      smart00325
      Location:77 → 266
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01255
      Location:268 → 439
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049291.1 Alternate UMICH_Zoey_3.1

      Range
      26123696..26504723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038517753.1 → XP_038373681.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    2. XM_038517752.1 → XP_038373680.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    3. XM_038517754.1 → XP_038373682.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    4. XM_038517750.1 → XP_038373678.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    5. XM_038517755.1 → XP_038373683.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X2

      Conserved Domains (6) summary
      smart00325
      Location:730 → 919
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:532 → 611
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:118 → 244
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:921 → 1092
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:452 → 521
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:258 → 355
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    6. XM_038517756.1 → XP_038373684.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X3

      Conserved Domains (2) summary
      smart00325
      Location:77 → 266
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01255
      Location:268 → 439
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049772.1 Alternate UNSW_CanFamBas_1.0

      Range
      26135327..26516773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038645710.1 → XP_038501638.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    2. XM_038645711.1 → XP_038501639.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    3. XM_038645712.1 → XP_038501640.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    4. XM_038645709.1 → XP_038501637.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    5. XM_038645713.1 → XP_038501641.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X2

      Conserved Domains (6) summary
      smart00325
      Location:730 → 919
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:532 → 611
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:118 → 244
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:921 → 1092
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:452 → 521
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:258 → 355
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    6. XM_038645714.1 → XP_038501642.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X3

      Conserved Domains (2) summary
      smart00325
      Location:77 → 266
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01255
      Location:268 → 439
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049252.1 Alternate UU_Cfam_GSD_1.0

      Range
      26641221..27022148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038581329.1 → XP_038437257.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    2. XM_038581328.1 → XP_038437256.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    3. XM_038581330.1 → XP_038437258.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    4. XM_038581327.1 → XP_038437255.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    5. XM_038581331.1 → XP_038437259.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X2

      Conserved Domains (6) summary
      smart00325
      Location:730 → 919
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:532 → 611
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:118 → 244
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:921 → 1092
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:452 → 521
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:258 → 355
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    6. XM_038581332.1 → XP_038437260.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0N581, A0A8C0R8A0, A0A8I3PFD3
      Conserved Domains (2) summary
      smart00325
      Location:77 → 266
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01255
      Location:268 → 439
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006613.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      26051519..26432492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005638823.4 → XP_005638880.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005638880.1

      UniProtKB/TrEMBL
      A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    2. XM_005638821.4 → XP_005638878.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005638878.1

      UniProtKB/TrEMBL
      A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    3. XM_014109762.3 → XP_013965237.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    4. XM_544855.7 → XP_544855.2  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_544855.2

      UniProtKB/TrEMBL
      A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
      Conserved Domains (6) summary
      smart00325
      Location:1044 → 1233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846 → 925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432 → 558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1235 → 1406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766 → 835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572 → 669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    5. XM_038461683.1 → XP_038317611.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X2

      Conserved Domains (6) summary
      smart00325
      Location:730 → 919
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:532 → 611
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:118 → 244
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:921 → 1092
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:452 → 521
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:258 → 355
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    6. XM_022413344.2 → XP_022269052.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0N581, A0A8C0R8A0, A0A8I3PFD3
      Conserved Domains (2) summary
      smart00325
      Location:77 → 266
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01255
      Location:268 → 439
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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