FBXW4 F-box and WD repeat domain containing 4 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: FBXW4provided by VGNC
Official Full Name: F-box and WD repeat domain containing 4provided by VGNC
Primary source: VGNC:VGNC:40795
See related: Ensembl:ENSCAFG00845020929
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 28

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	28	NC_051832.1 (14687904..14804731, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	28	NC_006610.4 (14388454..14505308, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	28	NC_049249.1 (14406279..14523118, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	28	NC_049288.1 (14232621..14351242, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	28	NC_049769.1 (14274140..14390820, complement)

Chromosome 28 - NC_051832.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: F-box/WD repeat-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051832.1 Reference ROS_Cfam_1.0

Range

14687904..14804731 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038440355.1 → XP_038296283.1 F-box/WD repeat-containing protein 4 isoform X2

Conserved Domains (2) summary

sd00039
Location:119 → 155

7WD40; WD40 repeat [structural motif]

cl29593
Location:65 → 304

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_038440354.1 → XP_038296282.1 F-box/WD repeat-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8C0NCZ9, A0A8C0Z3N3

Related

ENSCAFP00845028932.1, ENSCAFT00845036949.1

Conserved Domains (3) summary

sd00039
Location:321 → 354

7WD40; WD40 repeat [structural motif]

pfam12937
Location:193 → 225

F-box-like

cl29593
Location:306 → 553

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049288.1 Alternate UMICH_Zoey_3.1

Range

14232621..14351242 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038514977.1 → XP_038370905.1 F-box/WD repeat-containing protein 4 isoform X2

Conserved Domains (2) summary

sd00039
Location:119 → 155

7WD40; WD40 repeat [structural motif]

cl29593
Location:65 → 304

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_038514976.1 → XP_038370904.1 F-box/WD repeat-containing protein 4 isoform X1

Conserved Domains (3) summary

sd00039
Location:321 → 354

7WD40; WD40 repeat [structural motif]

pfam12937
Location:193 → 225

F-box-like

cl29593
Location:306 → 553

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049769.1 Alternate UNSW_CanFamBas_1.0

Range

14274140..14390820 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038642771.1 → XP_038498699.1 F-box/WD repeat-containing protein 4 isoform X2
XM_038642770.1 → XP_038498698.1 F-box/WD repeat-containing protein 4 isoform X1

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049249.1 Alternate UU_Cfam_GSD_1.0

Range

14406279..14523118 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038578580.1 → XP_038434508.1 F-box/WD repeat-containing protein 4 isoform X2

Conserved Domains (2) summary

sd00039
Location:119 → 155

7WD40; WD40 repeat [structural motif]

cl29593
Location:65 → 304

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_038578579.1 → XP_038434507.1 F-box/WD repeat-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8C0NCZ9, A0A8C0Z3N3

Conserved Domains (3) summary

sd00039
Location:321 → 354

7WD40; WD40 repeat [structural motif]

pfam12937
Location:193 → 225

F-box-like

cl29593
Location:306 → 553

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006610.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

14388454..14505308 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_022411670.1 → XP_022267378.1 F-box/WD repeat-containing protein 4 isoform X2

Conserved Domains (2) summary

sd00039
Location:119 → 155

7WD40; WD40 repeat [structural motif]

cl29593
Location:65 → 304

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_543981.7 → XP_543981.6 F-box/WD repeat-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8C0NCZ9, A0A8C0Z3N3

Conserved Domains (3) summary

sd00039
Location:321 → 354

7WD40; WD40 repeat [structural motif]

pfam12937
Location:193 → 225

F-box-like

cl29593
Location:306 → 553

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...