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    CHEK2 checkpoint kinase 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 486338, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CHEK2provided by VGNC
    Official Full Name
    checkpoint kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:39209
    See related
    Ensembl:ENSCAFG00845030072
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 26
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (22425372..22519047, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (21923947..22017275, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (22461722..22555609, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (22135806..22229383, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (22399429..22492792, complement)

    Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene 40S ribosomal protein S12-like Neighboring gene 40S ribosomal protein S18-like Neighboring gene U6 spliceosomal RNA Neighboring gene HscB mitochondrial iron-sulfur cluster cochaperone Neighboring gene coiled-coil domain containing 117 Neighboring gene X-box binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. case report, mutations and p53 mutation resulting in multiple primary neoplasms and SIRT1 down-regulation
      Title: A multicancer-like syndrome in a dog characterized by p53 and cell cycle-checkpoint kinase 2 (CHK2) mutations and sirtuin gene (SIRT1) down-regulation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Chk2
    Names
    CHK2 checkpoint homolog
    XP_005636449.1
    XP_005636450.1
    XP_005636451.1
    XP_005636452.1
    XP_005636453.1
    XP_005636454.1
    XP_013963328.1
    XP_013963330.1
    XP_022266203.1
    XP_022266205.1
    XP_038293049.1
    XP_038293050.1
    XP_038293051.1
    XP_038293052.1
    XP_038293053.1
    XP_038293054.1
    XP_038293055.1
    XP_038293056.1
    XP_038293057.1
    XP_038293058.1
    XP_038293059.1
    XP_038293060.1
    XP_038315309.1
    XP_038315310.1
    XP_038367954.1
    XP_038367955.1
    XP_038367956.1
    XP_038367957.1
    XP_038367958.1
    XP_038367959.1
    XP_038367960.1
    XP_038367961.1
    XP_038367963.1
    XP_038367964.1
    XP_038367965.1
    XP_038367966.1
    XP_038431453.1
    XP_038431454.1
    XP_038431455.1
    XP_038431456.1
    XP_038431457.1
    XP_038431458.1
    XP_038431459.1
    XP_038431460.1
    XP_038431461.1
    XP_038431462.1
    XP_038431463.1
    XP_038431464.1
    XP_038495645.1
    XP_038495646.1
    XP_038495647.1
    XP_038495648.1
    XP_038495649.1
    XP_038495650.1
    XP_038495652.1
    XP_038495653.1
    XP_038495654.1
    XP_038495655.1
    XP_038495656.1
    XP_038495657.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051830.1 Reference ROS_Cfam_1.0

      Range
      22425372..22519047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038437127.1 → XP_038293055.1  serine/threonine-protein kinase Chk2 isoform X4

      UniProtKB/TrEMBL
      A0A8C0R5W5
      Conserved Domains (2) summary
      cd00060
      Location:29 → 118
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:129 → 402
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    2. XM_038437124.1 → XP_038293052.1  serine/threonine-protein kinase Chk2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LD25, A0A8C0Z778
      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    3. XM_038437122.1 → XP_038293050.1  serine/threonine-protein kinase Chk2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0LD25
      Conserved Domains (2) summary
      cd00060
      Location:113 → 222
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:233 → 506
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    4. XM_038437125.1 → XP_038293053.1  serine/threonine-protein kinase Chk2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LD25, A0A8C0Z778
      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    5. XM_038437123.1 → XP_038293051.1  serine/threonine-protein kinase Chk2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LD25, A0A8C0Z778
      Related
      ENSCAFP00845041916.1, ENSCAFT00845053359.1
      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    6. XM_038437131.1 → XP_038293059.1  serine/threonine-protein kinase Chk2 isoform X6

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    7. XM_038437121.1 → XP_038293049.1  serine/threonine-protein kinase Chk2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LD25, A0A8C0PGQ8, A0A8I3QAH4
      Related
      ENSCAFP00845041946.1, ENSCAFT00845053394.1
      Conserved Domains (2) summary
      cd00060
      Location:140 → 249
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:260 → 533
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    8. XM_038437126.1 → XP_038293054.1  serine/threonine-protein kinase Chk2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LD25, A0A8C0Z778
      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    9. XM_038437130.1 → XP_038293058.1  serine/threonine-protein kinase Chk2 isoform X6

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    10. XM_038437132.1 → XP_038293060.1  serine/threonine-protein kinase Chk2 isoform X7

      Conserved Domains (1) summary
      cd14084
      Location:1 → 265
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    11. XM_038437129.1 → XP_038293057.1  serine/threonine-protein kinase Chk2 isoform X6

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    12. XM_038437128.1 → XP_038293056.1  serine/threonine-protein kinase Chk2 isoform X5

      UniProtKB/TrEMBL
      A0A8C0R5W5
      Conserved Domains (2) summary
      cd00060
      Location:12 → 101
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:112 → 385
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049286.1 Alternate UMICH_Zoey_3.1

      Range
      22135806..22229383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038512032.1 → XP_038367960.1  serine/threonine-protein kinase Chk2 isoform X4

      Conserved Domains (2) summary
      cd00060
      Location:29 → 118
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:129 → 402
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    2. XM_038512029.1 → XP_038367957.1  serine/threonine-protein kinase Chk2 isoform X3

      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    3. XM_038512027.1 → XP_038367955.1  serine/threonine-protein kinase Chk2 isoform X2

      Conserved Domains (2) summary
      cd00060
      Location:113 → 222
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:233 → 506
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    4. XM_038512030.1 → XP_038367958.1  serine/threonine-protein kinase Chk2 isoform X3

      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    5. XM_038512028.1 → XP_038367956.1  serine/threonine-protein kinase Chk2 isoform X3

      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    6. XM_038512037.1 → XP_038367965.1  serine/threonine-protein kinase Chk2 isoform X6

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    7. XM_038512026.1 → XP_038367954.1  serine/threonine-protein kinase Chk2 isoform X1

      Conserved Domains (2) summary
      cd00060
      Location:140 → 249
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:260 → 533
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    8. XM_038512031.1 → XP_038367959.1  serine/threonine-protein kinase Chk2 isoform X3

      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    9. XM_038512036.1 → XP_038367964.1  serine/threonine-protein kinase Chk2 isoform X6

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    10. XM_038512038.1 → XP_038367966.1  serine/threonine-protein kinase Chk2 isoform X7

      Conserved Domains (1) summary
      cd14084
      Location:1 → 265
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    11. XM_038512035.1 → XP_038367963.1  serine/threonine-protein kinase Chk2 isoform X6

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    12. XM_038512033.1 → XP_038367961.1  serine/threonine-protein kinase Chk2 isoform X5

      Conserved Domains (2) summary
      cd00060
      Location:12 → 101
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:112 → 385
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

      Range
      22399429..22492792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038639724.1 → XP_038495652.1  serine/threonine-protein kinase Chk2 isoform X4

      Conserved Domains (2) summary
      cd00060
      Location:29 → 118
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:129 → 402
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    2. XM_038639720.1 → XP_038495648.1  serine/threonine-protein kinase Chk2 isoform X3

      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    3. XM_038639718.1 → XP_038495646.1  serine/threonine-protein kinase Chk2 isoform X2

      Conserved Domains (2) summary
      cd00060
      Location:113 → 222
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:233 → 506
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    4. XM_038639721.1 → XP_038495649.1  serine/threonine-protein kinase Chk2 isoform X3

      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    5. XM_038639719.1 → XP_038495647.1  serine/threonine-protein kinase Chk2 isoform X3

      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    6. XM_038639728.1 → XP_038495656.1  serine/threonine-protein kinase Chk2 isoform X6

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    7. XM_038639717.1 → XP_038495645.1  serine/threonine-protein kinase Chk2 isoform X1

      Conserved Domains (2) summary
      cd00060
      Location:140 → 249
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:260 → 533
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    8. XM_038639722.1 → XP_038495650.1  serine/threonine-protein kinase Chk2 isoform X3

      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    9. XM_038639727.1 → XP_038495655.1  serine/threonine-protein kinase Chk2 isoform X6

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    10. XM_038639729.1 → XP_038495657.1  serine/threonine-protein kinase Chk2 isoform X7

      Conserved Domains (1) summary
      cd14084
      Location:1 → 265
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    11. XM_038639726.1 → XP_038495654.1  serine/threonine-protein kinase Chk2 isoform X6

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    12. XM_038639725.1 → XP_038495653.1  serine/threonine-protein kinase Chk2 isoform X5

      Conserved Domains (2) summary
      cd00060
      Location:12 → 101
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:112 → 385
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

      Range
      22461722..22555609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038575531.1 → XP_038431459.1  serine/threonine-protein kinase Chk2 isoform X4

      UniProtKB/TrEMBL
      A0A8C0R5W5
      Conserved Domains (2) summary
      cd00060
      Location:29 → 118
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:129 → 402
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    2. XM_038575528.1 → XP_038431456.1  serine/threonine-protein kinase Chk2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LD25, A0A8C0Z778
      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    3. XM_038575526.1 → XP_038431454.1  serine/threonine-protein kinase Chk2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0LD25
      Conserved Domains (2) summary
      cd00060
      Location:113 → 222
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:233 → 506
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    4. XM_038575529.1 → XP_038431457.1  serine/threonine-protein kinase Chk2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LD25, A0A8C0Z778
      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    5. XM_038575527.1 → XP_038431455.1  serine/threonine-protein kinase Chk2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LD25, A0A8C0Z778
      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    6. XM_038575535.1 → XP_038431463.1  serine/threonine-protein kinase Chk2 isoform X6

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    7. XM_038575525.1 → XP_038431453.1  serine/threonine-protein kinase Chk2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LD25, A0A8C0PGQ8, A0A8I3QAH4
      Conserved Domains (2) summary
      cd00060
      Location:140 → 249
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:260 → 533
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    8. XM_038575530.1 → XP_038431458.1  serine/threonine-protein kinase Chk2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LD25, A0A8C0Z778
      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    9. XM_038575534.1 → XP_038431462.1  serine/threonine-protein kinase Chk2 isoform X6

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    10. XM_038575536.1 → XP_038431464.1  serine/threonine-protein kinase Chk2 isoform X7

      Conserved Domains (1) summary
      cd14084
      Location:1 → 265
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    11. XM_038575533.1 → XP_038431461.1  serine/threonine-protein kinase Chk2 isoform X6

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    12. XM_038575532.1 → XP_038431460.1  serine/threonine-protein kinase Chk2 isoform X5

      UniProtKB/TrEMBL
      A0A8C0R5W5
      Conserved Domains (2) summary
      cd00060
      Location:12 → 101
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:112 → 385
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      21923947..22017275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005636395.4 → XP_005636452.1  serine/threonine-protein kinase Chk2 isoform X4

      UniProtKB/TrEMBL
      A0A8C0R5W5
      Conserved Domains (2) summary
      cd00060
      Location:29 → 118
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:129 → 402
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    2. XM_005636393.4 → XP_005636450.1  serine/threonine-protein kinase Chk2 isoform X3

      See identical proteins and their annotated locations for XP_005636450.1

      UniProtKB/TrEMBL
      A0A8C0LD25, A0A8C0Z778
      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    3. XM_038459382.1 → XP_038315310.1  serine/threonine-protein kinase Chk2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0LD25
      Conserved Domains (2) summary
      cd00060
      Location:113 → 222
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:233 → 506
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    4. XM_005636394.4 → XP_005636451.1  serine/threonine-protein kinase Chk2 isoform X3

      See identical proteins and their annotated locations for XP_005636451.1

      UniProtKB/TrEMBL
      A0A8C0LD25, A0A8C0Z778
      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    5. XM_005636392.4 → XP_005636449.1  serine/threonine-protein kinase Chk2 isoform X3

      See identical proteins and their annotated locations for XP_005636449.1

      UniProtKB/TrEMBL
      A0A8C0LD25, A0A8C0Z778
      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    6. XM_005636396.4 → XP_005636453.1  serine/threonine-protein kinase Chk2 isoform X6

      See identical proteins and their annotated locations for XP_005636453.1

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    7. XM_038459381.1 → XP_038315309.1  serine/threonine-protein kinase Chk2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LD25, A0A8C0PGQ8, A0A8I3QAH4
      Conserved Domains (2) summary
      cd00060
      Location:140 → 249
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:260 → 533
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    8. XM_022410495.2 → XP_022266203.1  serine/threonine-protein kinase Chk2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LD25, A0A8C0Z778
      Conserved Domains (2) summary
      cd00060
      Location:94 → 203
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:214 → 487
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    9. XM_022410497.2 → XP_022266205.1  serine/threonine-protein kinase Chk2 isoform X6

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    10. XM_014107855.3 → XP_013963330.1  serine/threonine-protein kinase Chk2 isoform X7

      Conserved Domains (1) summary
      cd14084
      Location:1 → 265
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    11. XM_005636397.4 → XP_005636454.1  serine/threonine-protein kinase Chk2 isoform X6

      See identical proteins and their annotated locations for XP_005636454.1

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    12. XM_014107853.3 → XP_013963328.1  serine/threonine-protein kinase Chk2 isoform X5

      UniProtKB/TrEMBL
      A0A8C0R5W5
      Conserved Domains (2) summary
      cd00060
      Location:12 → 101
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:112 → 385
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
    Nucleotide Protein
    Heading Accession and Version

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