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    GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 482663, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GUCY1A1provided by VGNC
    Official Full Name
    guanylate cyclase 1 soluble subunit alpha 1provided by VGNC
    Primary source
    VGNC:VGNC:41567
    See related
    Ensembl:ENSCAFG00845010475
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    GUCY1A3
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 15
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 15 NC_051819.1 (53880516..53943086)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 15 NC_006597.4 (53510720..53570219)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 15 NC_049236.1 (53557797..53618055)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 15 NC_049275.1 (53134895..53194847)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 15 NC_049756.1 (53244742..53304495)

    Chromosome 15 - NC_051819.1Genomic Context describing neighboring genes Neighboring gene microtubule associated protein 9 Neighboring gene ragulator complex protein LAMTOR3-like Neighboring gene guanylate cyclase 1 soluble subunit beta 1 Neighboring gene trifunctional enzyme subunit beta, mitochondrial-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NO responsiveness in pulmonary artery and airway smooth muscle: the role of cGMP regulation. Kwak YL, et al. Am J Physiol Lung Cell Mol Physiol, 2006 Jan. PMID 16113048

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cGMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to oxygen levels IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of guanylate cyclase complex, soluble IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanylate cyclase soluble subunit alpha-1
    Names
    GCS-alpha-1
    GCS-alpha-3
    guanylate cyclase soluble subunit alpha-3
    soluble guanylate cyclase 1 alpha 3
    soluble guanylate cyclase large subunit
    NP_001018045.1
    XP_038543121.1
    XP_038543122.1
    XP_038543123.1
    XP_038543124.1
    XP_038543125.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018035.1 → NP_001018045.1  guanylate cyclase soluble subunit alpha-1

      See identical proteins and their annotated locations for NP_001018045.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ008575
      UniProtKB/Swiss-Prot
      Q4ZHS0
      UniProtKB/TrEMBL
      A0A8I3NHF2, A0A8P0SDK9
      Related
      ENSCAFP00845014411.1, ENSCAFT00845018465.1
      Conserved Domains (4) summary
      smart00044
      Location:445 → 634
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:472 → 659
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:71 → 235
      HNOB; Haem-NO-binding
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051819.1 Reference ROS_Cfam_1.0

      Range
      53880516..53943086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038687197.1 → XP_038543125.1  guanylate cyclase soluble subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JM76, A0A8C0MV80, A0A8I3NA83, A0A8I3NHF2, A0A8P0SDK9
      Conserved Domains (3) summary
      pfam00211
      Location:472 → 659
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:71 → 234
      HNOB; Haem-NO-binding
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    2. XM_038687194.1 → XP_038543122.1  guanylate cyclase soluble subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JM76, A0A8C0MV80, A0A8I3NA83, A0A8I3NHF2, A0A8P0SDK9
      Conserved Domains (3) summary
      pfam00211
      Location:472 → 659
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:71 → 234
      HNOB; Haem-NO-binding
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    3. XM_038687195.1 → XP_038543123.1  guanylate cyclase soluble subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JM76, A0A8C0MV80, A0A8I3NA83, A0A8I3NHF2, A0A8P0SDK9
      Conserved Domains (3) summary
      pfam00211
      Location:472 → 659
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:71 → 234
      HNOB; Haem-NO-binding
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    4. XM_038687193.1 → XP_038543121.1  guanylate cyclase soluble subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JM76, A0A8C0MV80, A0A8I3NA83, A0A8I3NHF2, A0A8P0SDK9
      Conserved Domains (3) summary
      pfam00211
      Location:472 → 659
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:71 → 234
      HNOB; Haem-NO-binding
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    5. XM_038687196.1 → XP_038543124.1  guanylate cyclase soluble subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JM76, A0A8C0MV80, A0A8I3NA83, A0A8I3NHF2, A0A8P0SDK9
      Conserved Domains (3) summary
      pfam00211
      Location:472 → 659
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:71 → 234
      HNOB; Haem-NO-binding
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049275.1 Alternate UMICH_Zoey_3.1

      Range
      53134895..53194847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049756.1 Alternate UNSW_CanFamBas_1.0

      Range
      53244742..53304495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049236.1 Alternate UU_Cfam_GSD_1.0

      Range
      53557797..53618055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      53510720..53570219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4ZHS0.1 GenPept UniProtKB/Swiss-Prot:Q4ZHS0

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