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    TINAG tubulointerstitial nephritis antigen [ Canis lupus familiaris (dog) ]

    Gene ID: 481848, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TINAGprovided by VGNC
    Official Full Name
    tubulointerstitial nephritis antigenprovided by VGNC
    Primary source
    VGNC:VGNC:47379
    See related
    Ensembl:ENSCAFG00845011241
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (22290935..22384182)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (21678221..21770538)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (22024071..22116481)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (21776256..21868361)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (21892394..21984392)

    Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119874185 Neighboring gene muscular LMNA interacting protein Neighboring gene uncharacterized LOC111098291 Neighboring gene U6 spliceosomal RNA Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LOW QUALITY PROTEIN: tubulointerstitial nephritis antigen; tubulointerstitial nephritis antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051816.1 Reference ROS_Cfam_1.0

      Range
      22290935..22384182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038682854.1 → XP_038538782.1  LOW QUALITY PROTEIN: tubulointerstitial nephritis antigen isoform X1

      UniProtKB/TrEMBL
      A0A8I3NU54
      Related
      ENSCAFP00845015771.1, ENSCAFT00845020119.1
      Conserved Domains (3) summary
      smart00215
      Location:108 → 149
      VWC_out; von Willebrand factor (vWF) type C domain
      cd02620
      Location:206 → 454
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      cl02508
      Location:44 → 89
      Somatomedin_B; Somatomedin B domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049272.1 Alternate UMICH_Zoey_3.1

      Range
      21776256..21868361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038492065.1 → XP_038347993.1  tubulointerstitial nephritis antigen isoform X2

    2. XM_038492066.1 → XP_038347994.1  tubulointerstitial nephritis antigen isoform X3

      Conserved Domains (3) summary
      smart00215
      Location:120 → 161
      VWC_out; von Willebrand factor (vWF) type C domain
      cl02508
      Location:61 → 106
      Somatomedin_B; Somatomedin B domain
      cl23744
      Location:218 → 417
      Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

      Range
      21892394..21984392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038618214.1 → XP_038474142.1  tubulointerstitial nephritis antigen isoform X4

    2. XM_038618215.1 → XP_038474143.1  tubulointerstitial nephritis antigen isoform X5

      Conserved Domains (3) summary
      smart00215
      Location:120 → 161
      VWC_out; von Willebrand factor (vWF) type C domain
      cl02508
      Location:61 → 106
      Somatomedin_B; Somatomedin B domain
      cl23744
      Location:218 → 417
      Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

      Range
      22024071..22116481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038554350.1 → XP_038410278.1  tubulointerstitial nephritis antigen isoform X6

      UniProtKB/TrEMBL
      A0A8C0KKD8, A0A8C0NDM9, A0A8P0N5D0

    2. XM_038554351.1 → XP_038410279.1  tubulointerstitial nephritis antigen isoform X7

      UniProtKB/TrEMBL
      A0A8P0N5D0
      Conserved Domains (3) summary
      smart00215
      Location:120 → 161
      VWC_out; von Willebrand factor (vWF) type C domain
      cl02508
      Location:61 → 106
      Somatomedin_B; Somatomedin B domain
      cl23744
      Location:218 → 417
      Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      21678221..21770538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_538969.7 → XP_538969.2  tubulointerstitial nephritis antigen isoform X8

      UniProtKB/TrEMBL
      A0A8C0KKD8, A0A8C0NDM9, A0A8P0N5D0
      Conserved Domains (3) summary
      smart00215
      Location:120 → 161
      VWC_out; von Willebrand factor (vWF) type C domain
      cd02620
      Location:218 → 466
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      cl02508
      Location:61 → 106
      Somatomedin_B; Somatomedin B domain

    2. XM_038684341.1 → XP_038540269.1  tubulointerstitial nephritis antigen isoform X9

      UniProtKB/TrEMBL
      A0A8P0N5D0
      Conserved Domains (3) summary
      smart00215
      Location:120 → 161
      VWC_out; von Willebrand factor (vWF) type C domain
      cl02508
      Location:61 → 106
      Somatomedin_B; Somatomedin B domain
      cl23744
      Location:218 → 417
      Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...
    Nucleotide Protein
    Heading Accession and Version

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