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    ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif 12 [ Canis lupus familiaris (dog) ]

    Gene ID: 479369, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ADAMTS12provided by VGNC
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 12provided by VGNC
    Primary source
    VGNC:VGNC:50867
    See related
    Ensembl:ENSCAFG00845001462
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (74394459..74697683)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (73503678..73767544) , (73777238..73812152)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (74798493..75101600)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (74140285..74398310)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (74264326..74571548)

    Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119871571 Neighboring gene relaxin family peptide receptor 3 Neighboring gene uncharacterized LOC119871572 Neighboring gene uncharacterized LOC111095649 Neighboring gene threonyl-tRNA synthetase 1 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051808.1 Reference ROS_Cfam_1.0

      Range
      74394459..74697683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038662392.1 → XP_038518320.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X1

      UniProtKB/TrEMBL
      A0A8I3MZ18, A0A8P0TTC0
      Related
      ENSCAFP00845002050.1, ENSCAFT00845002573.1
      Conserved Domains (8) summary
      smart00209
      Location:547 → 598
      TSP1; Thrombospondin type 1 repeats
      PHA03247
      Location:1018 → 1245
      PHA03247; large tegument protein UL36; Provisional
      cd04273
      Location:248 → 455
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:704 → 814
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:53 → 195
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:470 → 534
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:1489 → 1543
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl15456
      Location:517 → 678
      ADAM_CR; ADAM cysteine-rich

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049264.1 Alternate UMICH_Zoey_3.1

      Range
      74140285..74398310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038474266.1 → XP_038330194.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X2

      Conserved Domains (7) summary
      smart00209
      Location:547 → 598
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:248 → 455
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:704 → 814
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:53 → 195
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:470 → 534
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:830 → 884
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl15456
      Location:517 → 678
      ADAM_CR; ADAM cysteine-rich

    RNA

    1. XR_005324829.1 RNA Sequence

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

      Range
      74264326..74571548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038598085.1 → XP_038454013.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X3

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

      Range
      74798493..75101600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038535470.1 → XP_038391398.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X1

      UniProtKB/TrEMBL
      A0A8P0TTC0

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      73503678..73767544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    2. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      73777238..73812152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038500411.1 → XP_038356339.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X4

      Conserved Domains (7) summary
      smart00209
      Location:547 → 598
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:248 → 455
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:704 → 814
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:53 → 195
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:470 → 534
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:830 → 884
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl15456
      Location:517 → 678
      ADAM_CR; ADAM cysteine-rich

    RNA

    1. XR_002626139.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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