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    RPP21 ribonuclease P/MRP subunit p21 [ Canis lupus familiaris (dog) ]

    Gene ID: 474824, updated on 22-Jan-2024

    Summary

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    Official Symbol
    RPP21provided by VGNC
    Official Full Name
    ribonuclease P/MRP subunit p21provided by VGNC
    Primary source
    VGNC:VGNC:54354
    See related
    Ensembl:ENSCAFG00845006718
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (460848..477760)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (454685..468677) , (469842..471576)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (459677..473707) , (474872..476606)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (318049..332065) , (333230..334982)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (389440..403464) , (404629..406363)

    Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 23 Neighboring gene U4 spliceosomal RNA Neighboring gene arginase 1 Neighboring gene Wilms tumor protein 1-interacting protein-like Neighboring gene uncharacterized LOC119874133 Neighboring gene G protein nucleolar 1 (putative) Neighboring gene proline rich 3 Neighboring gene ATP binding cassette subfamily F member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nucleolar ribonuclease P complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribonuclease P protein subunit p21
    Names
    ribonuclease P 21kDa subunit
    NP_001239310.1
    XP_005627151.1
    XP_022281519.1
    XP_038347163.1
    XP_038347164.1
    XP_038409329.1
    XP_038409330.1
    XP_038473224.1
    XP_038473225.1
    XP_038538634.1
    XP_038538635.1
    XP_038538636.1
    XP_038538637.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252381.1 → NP_001239310.1  ribonuclease P protein subunit p21

      Status: VALIDATED

      Source sequence(s)
      DN370541, DN378554
      UniProtKB/TrEMBL
      A0A8C0MKS4
      Conserved Domains (1) summary
      pfam04032
      Location:13 → 95
      Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051816.1 Reference ROS_Cfam_1.0

      Range
      460848..477760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038682708.1 → XP_038538636.1  ribonuclease P protein subunit p21 isoform X1

      UniProtKB/TrEMBL
      A0A8C0MUY6, A0A8C0SKR7, A0A8I3N0Z2, A0A8I3RV11
      Related
      ENSCAFP00845009479.1, ENSCAFT00845012133.1
      Conserved Domains (5) summary
      smart00502
      Location:151 → 272
      BBC; B-Box C-terminal domain
      COG5432
      Location:20 → 206
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd13745
      Location:305 → 483
      SPRY_PRY_TRIM39; PRY/SPRY domain in tripartite motif-binding protein 39 (TRIM39) and TRIM39-like
      cd16601
      Location:26 → 69
      RING-HC_TRIM39_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 39 (TRIM39) and similar proteins
      cd19780
      Location:103 → 146
      Bbox2_TRIM39-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM39, TRIM58 and similar proteins

    2. XM_038682709.1 → XP_038538637.1  ribonuclease P protein subunit p21 isoform X2

      Conserved Domains (5) summary
      PTZ00121
      Location:151 → 290
      PTZ00121; MAEBL; Provisional
      COG5432
      Location:20 → 206
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd16601
      Location:26 → 69
      RING-HC_TRIM39_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 39 (TRIM39) and similar proteins
      cd19780
      Location:103 → 146
      Bbox2_TRIM39-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM39, TRIM58 and similar proteins
      cl02614
      Location:305 → 368
      SPRY; SPRY domain

    3. XM_038682707.1 → XP_038538635.1  ribonuclease P protein subunit p21 isoform X4

      UniProtKB/TrEMBL
      A0A8C0KVK8, A0A8I3MT95, A0A8P0T6C1
      Related
      ENSCAFP00845009325.1, ENSCAFT00845011950.1
      Conserved Domains (6) summary
      COG5432
      Location:20 → 206
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      TIGR02169
      Location:149 → 270
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd16601
      Location:26 → 69
      RING-HC_TRIM39_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 39 (TRIM39) and similar proteins
      cd19780
      Location:103 → 146
      Bbox2_TRIM39-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM39, TRIM58 and similar proteins
      pfam04032
      Location:368 → 444
      Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain
      cl02614
      Location:305 → 368
      SPRY; SPRY domain

    4. XM_038682706.1 → XP_038538634.1  ribonuclease P protein subunit p21 isoform X3

      UniProtKB/TrEMBL
      A0A8C0KVK8, A0A8C0KYK9, A0A8I3MT95, A0A8I3MZW4, A0A8P0S6P7, A0A8P0T6C1
      Related
      ENSCAFP00845009389.1, ENSCAFT00845012029.1
      Conserved Domains (6) summary
      COG5432
      Location:20 → 206
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      TIGR02169
      Location:149 → 270
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd16601
      Location:26 → 69
      RING-HC_TRIM39_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 39 (TRIM39) and similar proteins
      cd19780
      Location:103 → 146
      Bbox2_TRIM39-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM39, TRIM58 and similar proteins
      pfam04032
      Location:368 → 444
      Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain
      cl02614
      Location:305 → 368
      SPRY; SPRY domain

    RNA

    1. XR_005435155.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049272.1 Alternate UMICH_Zoey_3.1

      Range
      318049..332065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    2. NC_049272.1 Alternate UMICH_Zoey_3.1

      Range
      333230..334982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038491235.1 → XP_038347163.1  ribonuclease P protein subunit p21 isoform X1

      Conserved Domains (5) summary
      smart00502
      Location:151 → 272
      BBC; B-Box C-terminal domain
      COG5432
      Location:20 → 206
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd13745
      Location:305 → 483
      SPRY_PRY_TRIM39; PRY/SPRY domain in tripartite motif-binding protein 39 (TRIM39) and TRIM39-like
      cd16601
      Location:26 → 69
      RING-HC_TRIM39_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 39 (TRIM39) and similar proteins
      cd19780
      Location:103 → 146
      Bbox2_TRIM39-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM39, TRIM58 and similar proteins

    2. XM_038491236.1 → XP_038347164.1  ribonuclease P protein subunit p21 isoform X2

      Conserved Domains (5) summary
      PTZ00121
      Location:151 → 290
      PTZ00121; MAEBL; Provisional
      COG5432
      Location:20 → 206
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd16601
      Location:26 → 69
      RING-HC_TRIM39_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 39 (TRIM39) and similar proteins
      cd19780
      Location:103 → 146
      Bbox2_TRIM39-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM39, TRIM58 and similar proteins
      cl02614
      Location:305 → 368
      SPRY; SPRY domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

      Range
      389440..403464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    2. NC_049753.1 Alternate UNSW_CanFamBas_1.0

      Range
      404629..406363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038617296.1 → XP_038473224.1  ribonuclease P protein subunit p21 isoform X1

      Conserved Domains (5) summary
      smart00502
      Location:151 → 272
      BBC; B-Box C-terminal domain
      COG5432
      Location:20 → 206
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd13745
      Location:305 → 483
      SPRY_PRY_TRIM39; PRY/SPRY domain in tripartite motif-binding protein 39 (TRIM39) and TRIM39-like
      cd16601
      Location:26 → 69
      RING-HC_TRIM39_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 39 (TRIM39) and similar proteins
      cd19780
      Location:103 → 146
      Bbox2_TRIM39-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM39, TRIM58 and similar proteins

    2. XM_038617297.1 → XP_038473225.1  ribonuclease P protein subunit p21 isoform X2

      Conserved Domains (5) summary
      PTZ00121
      Location:151 → 290
      PTZ00121; MAEBL; Provisional
      COG5432
      Location:20 → 206
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd16601
      Location:26 → 69
      RING-HC_TRIM39_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 39 (TRIM39) and similar proteins
      cd19780
      Location:103 → 146
      Bbox2_TRIM39-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM39, TRIM58 and similar proteins
      cl02614
      Location:305 → 368
      SPRY; SPRY domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

      Range
      459677..473707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    2. NC_049233.1 Alternate UU_Cfam_GSD_1.0

      Range
      474872..476606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038553401.1 → XP_038409329.1  ribonuclease P protein subunit p21 isoform X1

      UniProtKB/TrEMBL
      A0A8C0MUY6, A0A8C0SKR7, A0A8I3N0Z2, A0A8I3RV11
      Conserved Domains (5) summary
      smart00502
      Location:151 → 272
      BBC; B-Box C-terminal domain
      COG5432
      Location:20 → 206
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd13745
      Location:305 → 483
      SPRY_PRY_TRIM39; PRY/SPRY domain in tripartite motif-binding protein 39 (TRIM39) and TRIM39-like
      cd16601
      Location:26 → 69
      RING-HC_TRIM39_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 39 (TRIM39) and similar proteins
      cd19780
      Location:103 → 146
      Bbox2_TRIM39-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM39, TRIM58 and similar proteins

    2. XM_038553402.1 → XP_038409330.1  ribonuclease P protein subunit p21 isoform X2

      Conserved Domains (5) summary
      PTZ00121
      Location:151 → 290
      PTZ00121; MAEBL; Provisional
      COG5432
      Location:20 → 206
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd16601
      Location:26 → 69
      RING-HC_TRIM39_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 39 (TRIM39) and similar proteins
      cd19780
      Location:103 → 146
      Bbox2_TRIM39-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM39, TRIM58 and similar proteins
      cl02614
      Location:305 → 368
      SPRY; SPRY domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      454685..468677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    2. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      469842..471576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005627094.3 → XP_005627151.1  ribonuclease P protein subunit p21 isoform X1

      UniProtKB/TrEMBL
      A0A8C0MUY6, A0A8C0SKR7, A0A8I3N0Z2, A0A8I3RV11
      Conserved Domains (5) summary
      smart00502
      Location:151 → 272
      BBC; B-Box C-terminal domain
      COG5432
      Location:20 → 206
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd13745
      Location:305 → 483
      SPRY_PRY_TRIM39; PRY/SPRY domain in tripartite motif-binding protein 39 (TRIM39) and TRIM39-like
      cd16601
      Location:26 → 69
      RING-HC_TRIM39_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 39 (TRIM39) and similar proteins
      cd19780
      Location:103 → 146
      Bbox2_TRIM39-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM39, TRIM58 and similar proteins

    2. XM_022425811.2 → XP_022281519.1  ribonuclease P protein subunit p21 isoform X2

      Conserved Domains (5) summary
      PTZ00121
      Location:151 → 290
      PTZ00121; MAEBL; Provisional
      COG5432
      Location:20 → 206
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd16601
      Location:26 → 69
      RING-HC_TRIM39_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 39 (TRIM39) and similar proteins
      cd19780
      Location:103 → 146
      Bbox2_TRIM39-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM39, TRIM58 and similar proteins
      cl02614
      Location:305 → 368
      SPRY; SPRY domain
    Nucleotide Protein Strain
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