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    HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 465650, updated on 29-Mar-2024

    Summary

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    Official Symbol
    HUWE1provided by VGNC
    Official Full Name
    HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1provided by VGNC
    Primary source
    VGNC:VGNC:55717
    Locus tag
    CK820_G0049566
    See related
    Ensembl:ENSPTRG00000021930
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See HUWE1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    88
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) X NC_072421.2 (53584605..53735190, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) X NC_072421.1 (53580709..53731262, complement)

    Chromosome X - NC_072421.2Genomic Context describing neighboring genes Neighboring gene TIMELESS-interacting protein-like Neighboring gene hydroxysteroid 17-beta dehydrogenase 10 Neighboring gene microRNA let-7f-2 Neighboring gene microRNA mir-98 Neighboring gene small ribosomal subunit protein bS18m-like Neighboring gene PHD finger protein 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HUWE1
    Names
    HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
    XP_016798443.1
    XP_016798448.1
    XP_016798450.1
    XP_016798451.1
    XP_016798453.1
    XP_063660937.1
    XP_063660938.1
    XP_063660939.1
    XP_063660940.1
    XP_063660941.1
    XP_063660942.1
    XP_063660943.1
    XP_063660944.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072421.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      53584605..53735190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016942964.3 → XP_016798453.1  E3 ubiquitin-protein ligase HUWE1 isoform X12

      UniProtKB/TrEMBL
      A0A2J8J9S1, A0A6D2Y3S4, K6ZGY8, K7C706
      Related
      ENSPTRP00000087182.1
      Conserved Domains (7) summary
      cd00078
      Location:4019 → 4372
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1317 → 1356
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1617 → 1678
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 814
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2968 → 3077
      DUF4414; Domain of unknown function (DUF4414)
      cl26464
      Location:2735 → 3066
      Atrophin-1; Atrophin-1 family

    2. XM_063804872.1 → XP_063660942.1  E3 ubiquitin-protein ligase HUWE1 isoform X10

    3. XM_063804871.1 → XP_063660941.1  E3 ubiquitin-protein ligase HUWE1 isoform X8

    4. XM_063804868.1 → XP_063660938.1  E3 ubiquitin-protein ligase HUWE1 isoform X5

    5. XM_016942959.3 → XP_016798448.1  E3 ubiquitin-protein ligase HUWE1 isoform X2

      UniProtKB/TrEMBL
      A0A2J8J9U3
      Conserved Domains (6) summary
      PHA03247
      Location:2824 → 3155
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4108 → 4461
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1407 → 1446
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1707 → 1768
      WWE; WWE domain
      pfam06012
      Location:92 → 374
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:438 → 904
      DUF913; Domain of Unknown Function (DUF913)

    6. XM_063804874.1 → XP_063660944.1  E3 ubiquitin-protein ligase HUWE1 isoform X13

    7. XM_063804873.1 → XP_063660943.1  E3 ubiquitin-protein ligase HUWE1 isoform X11

    8. XM_016942962.3 → XP_016798451.1  E3 ubiquitin-protein ligase HUWE1 isoform X9

      UniProtKB/TrEMBL
      A0A2I3S6N7
      Related
      ENSPTRP00000072651.1
      Conserved Domains (6) summary
      PHA03247
      Location:2792 → 3123
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4076 → 4429
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1407 → 1446
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1707 → 1768
      WWE; WWE domain
      pfam06012
      Location:92 → 374
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:438 → 904
      DUF913; Domain of Unknown Function (DUF913)

    9. XM_063804870.1 → XP_063660940.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

    10. XM_063804869.1 → XP_063660939.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    11. XM_016942961.3 → XP_016798450.1  E3 ubiquitin-protein ligase HUWE1 isoform X4

      UniProtKB/TrEMBL
      A0A2J8J9R5
      Related
      ENSPTRP00000066741.1
      Conserved Domains (6) summary
      PHA03247
      Location:2825 → 3156
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4094 → 4447
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1407 → 1446
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1707 → 1768
      WWE; WWE domain
      pfam06012
      Location:92 → 374
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:438 → 904
      DUF913; Domain of Unknown Function (DUF913)

    12. XM_016942954.3 → XP_016798443.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      K7C706
      Conserved Domains (6) summary
      PHA03247
      Location:2825 → 3156
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4109 → 4462
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1407 → 1446
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1707 → 1768
      WWE; WWE domain
      pfam06012
      Location:92 → 374
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:438 → 904
      DUF913; Domain of Unknown Function (DUF913)

    13. XM_063804867.1 → XP_063660937.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

    RNA

    1. XR_010154904.1 RNA Sequence

    2. XR_010154903.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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