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    NCOA2 nuclear receptor coactivator 2 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 464226, updated on 3-Apr-2024

    Summary

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    Official Symbol
    NCOA2provided by VGNC
    Official Full Name
    nuclear receptor coactivator 2provided by VGNC
    Primary source
    VGNC:VGNC:835
    Locus tag
    CK820_G0022262
    See related
    Ensembl:ENSPTRG00000020333
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See NCOA2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 7 NC_072405.2 (78745220..79042310, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 8 NC_072406.1 (83762607..84059683, complement)

    Chromosome 7 - NC_072405.2Genomic Context describing neighboring genes Neighboring gene PR/SET domain 14 Neighboring gene histone H2A.Z-like Neighboring gene transcription factor BTF3-like Neighboring gene small ribosomal subunit protein uS13-like Neighboring gene uncharacterized LOC104007640

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nuclear receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear receptor coactivator 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072405.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      78745220..79042310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054656809.2 → XP_054512784.1  nuclear receptor coactivator 2 isoform X2

      UniProtKB/TrEMBL
      A0A2I3RZ80, A0A2J8M9L5, A0A6D2XX43

    2. XM_063817157.1 → XP_063673227.1  nuclear receptor coactivator 2 isoform X1

    3. XM_063817184.1 → XP_063673254.1  nuclear receptor coactivator 2 isoform X5

    4. XM_063817181.1 → XP_063673251.1  nuclear receptor coactivator 2 isoform X4

    5. XM_063817177.1 → XP_063673247.1  nuclear receptor coactivator 2 isoform X3

    6. XM_063817174.1 → XP_063673244.1  nuclear receptor coactivator 2 isoform X2

      UniProtKB/TrEMBL
      A0A2I3RZ80, A0A2J8M9L5, A0A6D2XX43

    7. XM_063817165.1 → XP_063673235.1  nuclear receptor coactivator 2 isoform X1

    8. XM_063817169.1 → XP_063673239.1  nuclear receptor coactivator 2 isoform X1

    9. XM_063817172.1 → XP_063673242.1  nuclear receptor coactivator 2 isoform X1

    10. XM_063817182.1 → XP_063673252.1  nuclear receptor coactivator 2 isoform X5

    11. XM_063817178.1 → XP_063673248.1  nuclear receptor coactivator 2 isoform X4

    12. XM_016959559.3 → XP_016815048.1  nuclear receptor coactivator 2 isoform X3

      UniProtKB/TrEMBL
      H2QWA2
      Conserved Domains (9) summary
      smart00353
      Location:35 → 88
      HLH; helix loop helix domain
      cd00130
      Location:123 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:119 → 215
      PAS; PAS fold
      pfam07469
      Location:1212 → 1269
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1002 → 1047
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    13. XM_016959550.4 → XP_016815039.1  nuclear receptor coactivator 2 isoform X2

      UniProtKB/TrEMBL
      A0A2I3RZ80, A0A2J8M9L5, A0A6D2XX43, H2QWA2
      Conserved Domains (10) summary
      smart00353
      Location:35 → 88
      HLH; helix loop helix domain
      cd00130
      Location:123 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1281 → 1338
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1071 → 1116
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640 → 709
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:892 → 1372
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      cl26950
      Location:1269 → 1399
      LsmAD; LsmAD domain

    14. XM_063817155.1 → XP_063673225.1  nuclear receptor coactivator 2 isoform X1

    15. XM_063817163.1 → XP_063673233.1  nuclear receptor coactivator 2 isoform X1

    16. XM_063817161.1 → XP_063673231.1  nuclear receptor coactivator 2 isoform X1

    17. XM_063817162.1 → XP_063673232.1  nuclear receptor coactivator 2 isoform X1

    18. XM_016959551.4 → XP_016815040.1  nuclear receptor coactivator 2 isoform X2

      UniProtKB/TrEMBL
      A0A2I3RZ80, A0A2J8M9L5, A0A6D2XX43, H2QWA2
      Conserved Domains (10) summary
      smart00353
      Location:35 → 88
      HLH; helix loop helix domain
      cd00130
      Location:123 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1281 → 1338
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1071 → 1116
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640 → 709
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:892 → 1372
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      cl26950
      Location:1269 → 1399
      LsmAD; LsmAD domain

    19. XM_063817175.1 → XP_063673245.1  nuclear receptor coactivator 2 isoform X3

    20. XM_063817156.1 → XP_063673226.1  nuclear receptor coactivator 2 isoform X1

    21. XM_063817179.1 → XP_063673249.1  nuclear receptor coactivator 2 isoform X4

    22. XM_054656812.2 → XP_054512787.1  nuclear receptor coactivator 2 isoform X2

      UniProtKB/TrEMBL
      A0A2I3RZ80, A0A2J8M9L5, A0A6D2XX43

    23. XM_063817164.1 → XP_063673234.1  nuclear receptor coactivator 2 isoform X1

    24. XM_063817167.1 → XP_063673237.1  nuclear receptor coactivator 2 isoform X1

    25. XM_063817183.1 → XP_063673253.1  nuclear receptor coactivator 2 isoform X5

    26. XM_016959560.3 → XP_016815049.1  nuclear receptor coactivator 2 isoform X3

      UniProtKB/TrEMBL
      H2QWA2
      Conserved Domains (9) summary
      smart00353
      Location:35 → 88
      HLH; helix loop helix domain
      cd00130
      Location:123 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:119 → 215
      PAS; PAS fold
      pfam07469
      Location:1212 → 1269
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1002 → 1047
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    27. XM_063817158.1 → XP_063673228.1  nuclear receptor coactivator 2 isoform X1

    28. XM_063817166.1 → XP_063673236.1  nuclear receptor coactivator 2 isoform X1

    29. XM_063817176.1 → XP_063673246.1  nuclear receptor coactivator 2 isoform X3

    30. XM_054656810.2 → XP_054512785.1  nuclear receptor coactivator 2 isoform X2

      UniProtKB/TrEMBL
      A0A2I3RZ80, A0A2J8M9L5, A0A6D2XX43

    31. XM_063817159.1 → XP_063673229.1  nuclear receptor coactivator 2 isoform X1

    32. XM_063817168.1 → XP_063673238.1  nuclear receptor coactivator 2 isoform X1

    33. XM_063817160.1 → XP_063673230.1  nuclear receptor coactivator 2 isoform X1

    34. XM_063817173.1 → XP_063673243.1  nuclear receptor coactivator 2 isoform X1

    35. XM_016959557.4 → XP_016815046.1  nuclear receptor coactivator 2 isoform X2

      UniProtKB/TrEMBL
      A0A2I3RZ80, A0A2J8M9L5, A0A6D2XX43, H2QWA2
      Related
      ENSPTRP00000069925.1
      Conserved Domains (10) summary
      smart00353
      Location:35 → 88
      HLH; helix loop helix domain
      cd00130
      Location:123 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1281 → 1338
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1071 → 1116
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640 → 709
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:892 → 1372
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      cl26950
      Location:1269 → 1399
      LsmAD; LsmAD domain

    36. XM_063817170.1 → XP_063673240.1  nuclear receptor coactivator 2 isoform X1

    37. XM_016959556.4 → XP_016815045.1  nuclear receptor coactivator 2 isoform X2

      UniProtKB/TrEMBL
      A0A2I3RZ80, A0A2J8M9L5, A0A6D2XX43, H2QWA2
      Conserved Domains (10) summary
      smart00353
      Location:35 → 88
      HLH; helix loop helix domain
      cd00130
      Location:123 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1281 → 1338
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1071 → 1116
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640 → 709
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:892 → 1372
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      cl26950
      Location:1269 → 1399
      LsmAD; LsmAD domain

    38. XM_063817171.1 → XP_063673241.1  nuclear receptor coactivator 2 isoform X1

    Nucleotide Protein
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