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    PDZD8 PDZ domain containing 8 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 450766, updated on 11-Apr-2024

    Summary

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    Official Symbol
    PDZD8provided by VGNC
    Official Full Name
    PDZ domain containing 8provided by VGNC
    Primary source
    VGNC:VGNC:5621
    Locus tag
    CK820_G0003868
    See related
    Ensembl:ENSPTRG00000002980
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 10
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 8 NC_072406.2 (129396634..129491396, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 10 NC_072408.1 (120014350..120106961, complement)

    Chromosome 8 - NC_072406.2Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 18 Neighboring gene solute carrier family 18 member A2 Neighboring gene empty spiracles homeobox 2 Neighboring gene uncharacterized LOC134807110

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitochondrion-endoplasmic reticulum membrane tethering IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondria-associated endoplasmic reticulum membrane contact site IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PDZ domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072406.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      129396634..129491396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_508062.9 → XP_508062.2  PDZ domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_508062.2

      UniProtKB/TrEMBL
      A0A2I3SQ57, A0A2J8PC59, A0A6D2X0H0, H2Q2M9
      Related
      ENSPTRP00000005257.1
      Conserved Domains (3) summary
      cd00029
      Location:841 → 883
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00992
      Location:364 → 441
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam07174
      Location:513 → 646
      FAP; Fibronectin-attachment protein (FAP)

    2. XM_063782168.1 → XP_063638238.1  PDZ domain-containing protein 8 isoform X2

    Nucleotide Protein
    Heading Accession and Version

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