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    vac14 vac14 homolog (S. cerevisiae) [ Danio rerio (zebrafish) ]

    Gene ID: 447912, updated on 11-Apr-2024

    Summary

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    Official Symbol
    vac14provided by ZNC
    Official Full Name
    vac14 homolog (S. cerevisiae)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040912-82
    See related
    Ensembl:ENSDARG00000014303 AllianceGenome:ZFIN:ZDB-GENE-040912-82
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb68e05; wu:fb68e05; zgc:100945
    Summary
    Predicted to be involved in phosphatidylinositol biosynthetic process and positive regulation of kinase activity. Predicted to be located in endosome and membrane. Predicted to be part of PAS complex. Predicted to be active in endosome membrane. Predicted to be extrinsic component of vacuolar membrane. Human ortholog(s) of this gene implicated in striatonigral degeneration. Orthologous to human VAC14 (VAC14 component of PIKFYVE complex). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 25
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (17590056..17611306)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (17493647..17514906)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 15a Neighboring gene zona pellucida glycoprotein d Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene transfer RNA aspartic acid (anticodon GUC) Neighboring gene transfer RNA aspartic acid (anticodon GUC)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in phosphatidylinositol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of PAS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PAS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein VAC14 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004650.1 → NP_001004650.1  protein VAC14 homolog

      See identical proteins and their annotated locations for NP_001004650.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078425
      UniProtKB/Swiss-Prot
      Q66L58
      Related
      ENSDARP00000003288.6, ENSDART00000009767.8
      Conserved Domains (3) summary
      pfam11916
      Location:533 → 707
      Vac14_Fig4_bd; Vacuolar protein 14 C-terminal Fig4p binding
      pfam12755
      Location:67 → 163
      Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
      sd00044
      Location:94 → 122
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      17590056..17611306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009297900.3 → XP_009296175.1  protein VAC14 homolog isoform X1

      UniProtKB/TrEMBL
      A0A0R4ITZ2, A0A8M3AWH2
      Related
      ENSDARP00000138390.1, ENSDART00000167750.2
      Conserved Domains (3) summary
      pfam11916
      Location:544 → 718
      Vac14_Fig4_bd; Vacuolar protein 14 C-terminal Fig4p binding
      pfam12755
      Location:67 → 163
      Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
      sd00044
      Location:94 → 122
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66L58.1 GenPept UniProtKB/Swiss-Prot:Q66L58

    Gene LinkOut

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