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    bcat2 branched chain amino-acid transaminase 2, mitochondrial [ Danio rerio (zebrafish) ]

    Gene ID: 436949, updated on 11-Apr-2024

    Summary

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    Official Symbol
    bcat2provided by ZNC
    Official Full Name
    branched chain amino-acid transaminase 2, mitochondrialprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-425
    See related
    Ensembl:ENSDARG00000054849 AllianceGenome:ZFIN:ZDB-GENE-040718-425
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb37h12; zgc:91919; wu:fb37h12
    Summary
    Predicted to enable branched-chain-amino-acid transaminase activity. Predicted to be involved in leucine biosynthetic process and valine biosynthetic process. Predicted to act upstream of or within branched-chain amino acid biosynthetic process and cellular amino acid biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human BCAT2 (branched chain amino acid transaminase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (29949984..29968050, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (29819142..29837208, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene granulin a antisense Neighboring gene granulin a Neighboring gene interferon-induced protein 35 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial Fatty Acid β-Oxidation Inhibition Promotes Glucose Utilization and Protein Deposition through Energy Homeostasis Remodeling in Fish. Li LY, et al. J Nutr, 2020 Sep 1. PMID 32720689, Free PMC Article
    2. Peroxisomal proliferator-activated receptor α-b deficiency induces the reprogramming of nutrient metabolism in zebrafish. Li LY, et al. J Physiol, 2020 Oct. PMID 32710562
    3. A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting. Hugo SE, et al. Genes Dev, 2012 Feb 1. PMID 22302940, Free PMC Article
    4. Tissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. Nakajima H, et al. PLoS One, 2011. PMID 22046393, Free PMC Article
    5. A systematic approach to identify functional motifs within vertebrate developmental enhancers. Li Q, et al. Dev Biol, 2010 Jan 15. PMID 19850031, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-isoleucine transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-leucine transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-valine transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables branched-chain-amino-acid transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables branched-chain-amino-acid transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-leucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within branched-chain amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within branched-chain amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in valine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    branched-chain-amino-acid aminotransferase, mitochondrial
    Names
    branched chain aminotransferase 2, mitochondrial
    NP_001002676.2
    NP_001296456.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002676.2 → NP_001002676.2  branched-chain-amino-acid aminotransferase, mitochondrial isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CR384107
      UniProtKB/TrEMBL
      A0A8M1N0V9, E9QCQ6, F1QLF8
      Related
      ENSDARP00000071587.3, ENSDART00000077119.3
      Conserved Domains (2) summary
      PRK13357
      Location:50 → 397
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:100 → 395
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

    2. NM_001309527.1 → NP_001296456.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end of the coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      CR384107
      UniProtKB/TrEMBL
      A0A8M1P782, E9QFU8
      Related
      ENSDARP00000122776.1, ENSDART00000139310.3
      Conserved Domains (2) summary
      PRK13357
      Location:35 → 382
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:85 → 380
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      29949984..29968050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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