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    Alg9 ALG9, alpha-1,2-mannosyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43031, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Alg9provided by FlyBase
    Official Full Name
    ALG9, alpha-1,2-mannosyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039293
    Locus tag
    Dmel_CG11851
    See related
    AllianceGenome:FB:FBgn0039293
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alg9; CG11851; dAlg9; Dmel\CG11851
    Summary
    Predicted to enable alpha-1,2-mannosyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Located in endomembrane system. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Il. Orthologous to human ALG9 (ALG9 alpha-1,2-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    96C6-96C7; 3-87 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25221589..25224118)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21047311..21049840)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cadherin 96Cb Neighboring gene Sil1 nucleotide exchange factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The essential Smp3 protein is required for addition of the side-branching fourth mannose during assembly of yeast glycosylphosphatidylinositols. Grimme SJ, et al. J Biol Chem, 2001 Jul 20. PMID 11356840
    2. A Drosophila Tumor Suppressor Gene Prevents Tonic TNF Signaling through Receptor N-Glycosylation. de Vreede G, et al. Dev Cell, 2018 Jun 4. PMID 29870719, Free PMC Article
    3. Diversity and functions of protein glycosylation in insects. Walski T, et al. Insect Biochem Mol Biol, 2017 Apr. PMID 28232040
    4. A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. Dalton HM, et al. PLoS Genet, 2022 Sep. PMID 36166480, Free PMC Article
    5. Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing. Yamamoto-Hino M, et al. Genes Cells, 2015 Jun. PMID 25940448, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ALG9, alpha-1,2-mannosyltransferase
    Names
    Alg9-PA
    CG11851-PA
    NP_651353.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25221589..25224118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143096.4 → NP_651353.1  ALG9, alpha-1,2-mannosyltransferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651353.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBV8
      Related
      FBpp0084183
      Conserved Domains (1) summary
      pfam03901
      Location:75 → 498
      Glyco_transf_22; Alg9-like mannosyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBV8 Q9VBV8

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