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    CG11839 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43006, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG11839provided by FlyBase
    Primary source
    FLYBASE:FBgn0039271
    Locus tag
    Dmel_CG11839
    See related
    AllianceGenome:FB:FBgn0039271
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT36969; Dmel\CG11839; Znf830
    Summary
    Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in DNA-dependent DNA replication and mitotic DNA integrity checkpoint signaling. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human ZNF830 (zinc finger protein 830). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    96B20-96B20; 3-86 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25069927..25070914)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20895649..20896636)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene veli Neighboring gene Poly-glutamine tract binding protein 1 Neighboring gene Catalytic subunit 3B of the oligosaccharyltransferase complex Neighboring gene uncharacterized protein Neighboring gene shams

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The divergent U12-type spliceosome is required for pre-mRNA splicing and is essential for development in Drosophila. Otake LR, et al. Mol Cell, 2002 Feb. PMID 11864616
    2. Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity. Chung CY, et al. Nat Commun, 2018 Oct 23. PMID 30353006, Free PMC Article
    3. Evolutionary dynamics of U12-type spliceosomal introns. Lin CF, et al. BMC Evol Biol, 2010 Feb 17. PMID 20163699, Free PMC Article
    4. An SMN-dependent U12 splicing event essential for motor circuit function. Lotti F, et al. Cell, 2012 Oct 12. PMID 23063131, Free PMC Article
    5. A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Praveen K, et al. Cell Rep, 2012 Jun 28. PMID 22813737, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11839-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25069927..25070914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170198.3 → NP_733077.3  uncharacterized protein Dmel_CG11839 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733077.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9ER00, Q9VBY5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBY5 Q9VBY5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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