GRIA2 glutamate ionotropic receptor AMPA type subunit 2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: GRIA2provided by CGNC
Full Name: glutamate ionotropic receptor AMPA type subunit 2provided by CGNC
Primary source: CGNC:7152
See related: Ensembl:ENSGALG00010008237
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: GLUR2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (20867881..20962642)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (20943060..21034254)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased GluA2 expression and changes in the Ca(2+) permeability of AMPA receptors regulate the dendritic arborization of spinal cord motoneurons during embryonic development.
Title: Downregulation of GluA2 AMPA receptor subunits reduces the dendritic arborization of developing spinal motoneurons.
These findings raise the possibility that Ca2+ influx through Ca(2+)-permeable AMPA receptors plays an important role during early embryonic development in chick spinal motoneurons.
Title: Developmental characteristics of AMPA receptors in chick lumbar motoneurons.
Results show that 5'GMP appears to be a false agonist rather than a competitive antagonist of the GluR2 receptor.
Title: Binding of 5'-GMP to the GluR2 AMPA receptor: insight from targeted molecular dynamics simulations.
Ca(2+) uptake in response to AMPA receptor activation decreases dramatically during maturation in chicken brain microslices without a change in tissue AMPA receptor content
Title: Maturational changes in the subunit composition of AMPA receptors and the functional consequences of their activation in chicken forebrain.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables AMPA glutamate receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in dendritic spine	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: glutamate receptor 2

Names: AMPA glutamate receptor 2; AMPA receptor GluR2/B; glutamate receptor, ionotropic, AMPA 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001775.4 → NP_001001775.3 glutamate receptor 2 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1 (also known as flip isoform). RNA editing (CAG->CGG) changes Gln607Arg.

Source sequence(s)

JAENSK010000071

UniProtKB/TrEMBL

F1NKF1, Q90856

Related

ENSGALP00010011268.1, ENSGALT00010019720.1

Conserved Domains (2) summary

cd13715
Location:413 → 794

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06389
Location:28 → 397

PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
NM_001111014.3 → NP_001104484.2 glutamate receptor 2 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region compared to transcript variant 1, and encodes an isoform (2, also known as flop isoform) that is the same length as isoform 1, but with few amino acid differences. RNA editing (CAG->CGG) changes Gln607Arg.

Source sequence(s)

JAENSK010000071

UniProtKB/TrEMBL

F1NY65, Q90856

Related

ENSGALP00010011271.1, ENSGALT00010019723.1

Conserved Domains (2) summary

cd13715
Location:413 → 794

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06389
Location:28 → 397

PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

20867881..20962642

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040698771.2 → XP_040554705.1 glutamate receptor 2 isoform X1

Conserved Domains (2) summary

cd06389
Location:28 → 397

PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor

cl21456
Location:413 → 529

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_040698772.2 → XP_040554706.1 glutamate receptor 2 isoform X2

Conserved Domains (1) summary

cd06389
Location:28 → 397

PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
XM_015285277.4 → XP_015140763.2 glutamate receptor 2 isoform X3

UniProtKB/TrEMBL

Q90856

Conserved Domains (3) summary

cd06389
Location:28 → 397

PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor

cd13715
Location:413 → 794

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:545 → 871

Lig_chan; Ligand-gated ion channel