ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: ST8SIA2provided by CGNC
Official Full Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2provided by CGNC
Primary source: CGNC:5194
See related: Ensembl:ENSGALG00010018525
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: SIAT8B
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	10	NC_052541.1 (14513606..14539806)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	10	NC_052582.1 (14391417..14417609)

Chromosome 10 - NC_052541.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of ST8SIA2 upon AP-2delta overexpression in retina increases ectopic polysialylation of NCAM which in turn causes premature bundling of axons and alters axonal response to guidance cues.
Title: Transcription factor AP-2delta regulates the expression of polysialyltransferase ST8SIA2 in chick retina.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in N-glycan processing	IEA Inferred from Electronic Annotation more info	PubMed
involved_in oligosaccharide metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: alpha-2,8-sialyltransferase 8B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001604.2 → NP_001001604.2 alpha-2,8-sialyltransferase 8B precursor

Status: PROVISIONAL

Source sequence(s)

JAENSK010000245

UniProtKB/TrEMBL

A0A8V0Z823, Q6ZXD1

Related

ENSGALP00010026752.1, ENSGALT00010044830.1

Conserved Domains (1) summary

pfam00777
Location:109 → 368

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

14513606..14539806

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015292082.4 → XP_015147568.2 alpha-2,8-sialyltransferase 8B isoform X1

UniProtKB/TrEMBL

Q6ZXD1

Conserved Domains (1) summary

pfam00777
Location:88 → 347

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)