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    SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [ Bos taurus (cattle) ]

    Gene ID: 414274, updated on 4-Apr-2024

    Summary

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    Official Symbol
    SMARCA4provided by VGNC
    Official Full Name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4provided by VGNC
    Primary source
    VGNC:VGNC:34987
    See related
    Ensembl:ENSBTAG00000019220
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    BRG1; BAF190A
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 7
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (15424807..15515093)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene GTPase HRas-like Neighboring gene uncharacterized LOC101902128 Neighboring gene WW domain-binding protein 11-like Neighboring gene ATM interactor-like Neighboring gene microRNA mir-2882 Neighboring gene U6 spliceosomal RNA Neighboring gene low density lipoprotein receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC148937

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription activator BRG1
    Names
    ATP-dependent helicase SMARCA4
    BRG1-associated factor 190A
    SNF2-beta
    SWI/SNF related transcriptional activator
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
    WI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
    protein brahma homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105614.1 → NP_001099084.1  transcription activator BRG1

      See identical proteins and their annotated locations for NP_001099084.1

      Status: PROVISIONAL

      Source sequence(s)
      BC153216
      UniProtKB/Swiss-Prot
      A7Z019
      UniProtKB/TrEMBL
      A0A3Q1LIV7
      Related
      ENSBTAP00000059124.2, ENSBTAT00000072138.2
      Conserved Domains (9) summary
      cd05516
      Location:1417 → 1523
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:452 → 524
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:742 → 1224
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:362 → 544
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:43 → 217
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:723 → 973
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:604 → 646
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1282 → 1348
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      15424807..15515093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059887957.1 → XP_059743940.1  transcription activator BRG1 isoform X5

      Related
      ENSBTAP00000096851.1, ENSBTAT00000110038.1

    2. XM_024993899.2 → XP_024849667.1  transcription activator BRG1 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1LIV7
      Conserved Domains (9) summary
      cd05516
      Location:1450 → 1556
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:452 → 524
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:742 → 1224
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:362 → 544
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:43 → 217
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:723 → 973
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:604 → 646
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1315 → 1381
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    3. XM_059887954.1 → XP_059743937.1  transcription activator BRG1 isoform X1

    4. XM_024993894.2 → XP_024849662.2  transcription activator BRG1 isoform X2

    5. XM_059887958.1 → XP_059743941.1  transcription activator BRG1 isoform X6

      Related
      ENSBTAP00000025598.7, ENSBTAT00000025598.7

    6. XM_024993897.2 → XP_024849665.2  transcription activator BRG1 isoform X7

    7. XM_059887955.1 → XP_059743938.1  transcription activator BRG1 isoform X3

    8. XM_059887956.1 → XP_059743939.1  transcription activator BRG1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7Z019.1 GenPept UniProtKB/Swiss-Prot:A7Z019

    Gene LinkOut

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