U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    TRPC6 transient receptor potential cation channel subfamily C member 6 [ Bos taurus (cattle) ]

    Gene ID: 407151, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TRPC6provided by VGNC
    Official Full Name
    transient receptor potential cation channel subfamily C member 6provided by VGNC
    Primary source
    VGNC:VGNC:36386
    See related
    BGD:BT28249; Ensembl:ENSBTAG00000011227
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    trp6
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TRPC6 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (7313317..7473504)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene latexin-like Neighboring gene uncharacterized LOC132342300 Neighboring gene uncharacterized LOC132342299 Neighboring gene adenosylhomocysteinase-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Activation of the cytosolic calcium-independent phospholipase A(2) β isoform contributes to TRPC6 externalization via release of arachidonic acid. Putta P, et al. J Biol Chem, 2021 Oct. PMID 34509476, Free PMC Article
    2. Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation. Chaudhuri P, et al. Proc Natl Acad Sci U S A, 2016 Feb 23. PMID 26858457, Free PMC Article
    3. TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like channels in adrenal cells. Philipp S, et al. J Biol Chem, 2000 Aug 4. PMID 10816590
    4. Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement. Chaudhuri P, et al. Mol Biol Cell, 2008 Aug. PMID 18495872, Free PMC Article
    5. Two types of non-selective cation channel opened by muscarinic stimulation with carbachol in bovine ciliary muscle cells. Takai Y, et al. J Physiol, 2004 Sep 15. PMID 15272043, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activation of the cytosolic calcium-independent phospholipase A2 beta isoform contributes to TRPC6 externalization via release of arachidonic acid.
      Title: Activation of the cytosolic calcium-independent phospholipase A(2) β isoform contributes to TRPC6 externalization via release of arachidonic acid.
    2. These findings suggest that lysoPC induces CaM phosphorylation at Tyr(99) by a Src family kinase and that phosphorylated CaM activates PI3K to produce PIP3, which promotes TRPC6 translocation to the cell membrane.
      Title: Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation.
    3. analysis of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement
      Title: Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables inositol 1,4,5 trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables store-operated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in manganese ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cation channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    short transient receptor potential channel 6

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166572.1 → NP_001160044.1  short transient receptor potential channel 6

      See identical proteins and their annotated locations for NP_001160044.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000015
      UniProtKB/Swiss-Prot
      F1MND4, Q9MYW0
      Related
      ENSBTAP00000053428.3, ENSBTAT00000061311.4
      Conserved Domains (2) summary
      TIGR00870
      Location:81 → 897
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:131 → 158
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      7313317..7473504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024975041.2 → XP_024830809.1  short transient receptor potential channel 6 isoform X1

      Conserved Domains (2) summary
      TIGR00870
      Location:81 → 872
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:131 → 158
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MYW0.2 GenPept UniProtKB/Swiss-Prot:Q9MYW0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.