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    aebp2 AE binding protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 406815, updated on 27-Mar-2024

    Summary

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    Official Symbol
    aebp2provided by ZNC
    Official Full Name
    AE binding protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2885
    See related
    Ensembl:ENSDARG00000006038 AllianceGenome:ZFIN:ZDB-GENE-040426-2885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63755; wu:fk42f11; wu:fk52h12
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleus. Predicted to be part of ESC/E(Z) complex. Orthologous to human AEBP2 (AE binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (2927270..2945327, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (2997159..3015216, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1C1 Neighboring gene phosphodiesterase 3A, cGMP-inhibited Neighboring gene pleckstrin homology domain containing, family A member 5 Neighboring gene intestine-specific homeobox-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESC/E(Z) complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein AEBP2
    Names
    AE-binding protein 2 homolog
    adipocyte enhancer-binding protein 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213494.2 → NP_998659.2  zinc finger protein AEBP2

      See identical proteins and their annotated locations for NP_998659.2

      Status: VALIDATED

      Source sequence(s)
      BX914207
      UniProtKB/Swiss-Prot
      Q1LUY9, Q1LUZ0, Q7SXV2
      Related
      ENSDARP00000022060.7, ENSDART00000019518.8
      Conserved Domains (3) summary
      COG5048
      Location:135 → 257
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:184 → 204
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:233 → 259
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      2927270..2945327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SXV2.2 GenPept UniProtKB/Swiss-Prot:Q7SXV2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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