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    HMGB1 high mobility group box 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 403170, updated on 5-Apr-2024

    Summary

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    Official Symbol
    HMGB1provided by VGNC
    Official Full Name
    high mobility group box 1provided by VGNC
    Primary source
    VGNC:VGNC:59082
    See related
    Ensembl:ENSCAFG00845021967
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    HMG1
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 25
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (9542952..9670011)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (9596948..9603279)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (9608257..9614621)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (9558389..9564743)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (9566227..9572605)

    Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene ubiquitin specific peptidase like 1 Neighboring gene uncharacterized LOC102155494 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC111092316

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TNF-α induced secretion of HMGB1 from non-immune canine mammary epithelial cells (MTH53A). Willenbrock S, et al. Cytokine, 2012 Feb. PMID 22154216
    2. Quantitative PCR and immunohistochemical analyses of HMGB1 and RAGE expression in canine disseminated histiocytic sarcoma (malignant histiocytosis). Sterenczak KA, et al. Anticancer Res, 2011 May. PMID 21617208
    3. Molecular characterization of the canine HMGB1. Murua Escobar H, et al. Cytogenet Genome Res, 2003. PMID 14571134

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The observed HMGB1 release kinetics showed a clearly time-dependent manner with a peak release 24h after TNF-alpha stimulation, while stimulation with IFN-gamma had only small effects on the HMGB1 release.
      Title: TNF-α induced secretion of HMGB1 from non-immune canine mammary epithelial cells (MTH53A).
    2. RAGE and HMGB1 expression down-regulation in canine disseminated histiocytic sarcoma points to a role in the progression of histiocytic disorders
      Title: Quantitative PCR and immunohistochemical analyses of HMGB1 and RAGE expression in canine disseminated histiocytic sarcoma (malignant histiocytosis).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding, bending IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    high mobility group protein B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002937.2 → NP_001002937.1  high mobility group protein B1

      See identical proteins and their annotated locations for NP_001002937.1

      Status: VALIDATED

      Source sequence(s)
      AY135519, DN349572, DN355565, DN878449, JAAUVH010000302
      UniProtKB/Swiss-Prot
      Q6YKA4
      UniProtKB/TrEMBL
      A0A8C0R7L8
      Related
      ENSCAFP00845030356.1, ENSCAFT00845038767.1
      Conserved Domains (2) summary
      pfam00505
      Location:95 → 162
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:6 → 78
      HMG_box_2; HMG-box domain

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051829.1 Reference ROS_Cfam_1.0

      Range
      9542952..9670011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038434508.1 → XP_038290436.1  high mobility group protein B1 isoform X1

      UniProtKB/Swiss-Prot
      Q6YKA4
      UniProtKB/TrEMBL
      A0A8C0R7L8
      Conserved Domains (2) summary
      pfam00505
      Location:95 → 162
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:6 → 78
      HMG_box_2; HMG-box domain

    2. XM_038434506.1 → XP_038290434.1  high mobility group protein B1 isoform X1

      UniProtKB/Swiss-Prot
      Q6YKA4
      UniProtKB/TrEMBL
      A0A8C0R7L8
      Conserved Domains (2) summary
      pfam00505
      Location:95 → 162
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:6 → 78
      HMG_box_2; HMG-box domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049285.1 Alternate UMICH_Zoey_3.1

      Range
      9558389..9564743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

      Range
      9566227..9572605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

      Range
      9608257..9614621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      9596948..9603279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6YKA4.3 GenPept UniProtKB/Swiss-Prot:Q6YKA4

    Gene LinkOut

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