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    CG5498 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40250, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG5498provided by FlyBase
    Primary source
    FLYBASE:FBgn0027565
    Locus tag
    Dmel_CG5498
    See related
    AllianceGenome:FB:FBgn0027565
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH08385; Dmel\CG5498
    Summary
    Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and vesicle budding from membrane. Predicted to be part of ESCRT III complex. Predicted to be active in cytoplasmic side of plasma membrane and multivesicular body. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic brain; embryonic/larval midgut; and extended germ band embryo. Orthologous to human CHMP7 (charged multivesicular body protein 7). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    77B9-77B9; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20382405..20384109, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20375505..20377209, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Insulin degrading metalloproteinase Neighboring gene Rho-related BTB domain containing Neighboring gene fumble Neighboring gene antisense RNA:CR43944 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. fumble encodes a pantothenate kinase homolog required for proper mitosis and meiosis in Drosophila melanogaster. Afshar K, et al. Genetics, 2001 Mar. PMID 11238410, Free PMC Article
    2. Nucleoporins are degraded via upregulation of ESCRT-III/Vps4 complex in Drosophila models of C9-ALS/FTD. Dubey SK, et al. Cell Rep, 2022 Sep 20. PMID 36130523, Free PMC Article
    3. The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis. Capalbo L, et al. Open Biol, 2012 May. PMID 22724069, Free PMC Article
    4. A Hopscotch-chromatin connection. Betz A, et al. Nat Genet, 2006 Sep. PMID 16941005
    5. Molecular analysis of flies selected for aggressive behavior. Dierick HA, et al. Nat Genet, 2006 Sep. PMID 16906161

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in endosomal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle budding from membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT III complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5498-PB
    transcript 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20382405..20384109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168850.3 → NP_730525.2  uncharacterized protein Dmel_CG5498 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730525.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPV1, Q9VPG6, Q9Y124
      Related
      FBpp0077896
      Conserved Domains (1) summary
      cl21588
      Location:244 → 397
      Snf7; Snf7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y124 Q9Y124

    Gene LinkOut

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