U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Dnaaf6 Dynein axonemal assembly factor 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39598, updated on 4-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dnaaf6provided by FlyBase
    Official Full Name
    Dynein axonemal assembly factor 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0036437
    Locus tag
    Dmel_CG5048
    See related
    AllianceGenome:FB:FBgn0036437
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.238; CG5048; Dmel\CG5048
    Summary
    Predicted to enable chaperone binding activity and dynein intermediate chain binding activity. Predicted to be involved in axonemal dynein complex assembly and flagellated sperm motility. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic head sensory system; gnathal segment; sensory nervous system primordium; spermatogonium; and ventral sensory complex primordium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 36. Orthologous to human DNAAF6 (dynein axonemal assembly factor 6). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    70F1-70F1; 3-42 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14684768..14685842)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14677868..14678942)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:initiator Methionine-CAT 1-5 Neighboring gene uncharacterized protein Neighboring gene omega Neighboring gene goddard Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Strongly Truncated Dnaaf4 Plays a Conserved Role in Drosophila Ciliary Dynein Assembly as Part of an R2TP-Like Co-Chaperone Complex With Dnaaf6. Lennon J, et al. Front Genet, 2022. PMID 35873488, Free PMC Article
    2. The Drosophila Translational Control Element (TCE) is required for high-level transcription of many genes that are specifically expressed in testes. Katzenberger RJ, et al. PLoS One, 2012. PMID 22984601, Free PMC Article
    3. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article
    4. Identification of genes that promote or inhibit olfactory memory formation in Drosophila. Walkinshaw E, et al. Genetics, 2015 Apr. PMID 25644700, Free PMC Article
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonemal dynein complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axonemal dynein complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of R2TP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    dynein axonemal assembly factor 6
    Names
    CG5048-PA
    Dnaaf6-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14684768..14685842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140455.2 → NP_648712.1  dynein axonemal assembly factor 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648712.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUG3
      Related
      FBpp0075434
      Conserved Domains (1) summary
      cl00175
      Location:104 → 191
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUG3 Q9VUG3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools