U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    RPE65 RPE65, retinoid isomerohydrolase [ Gallus gallus (chicken) ]

    Gene ID: 395700, updated on 3-Apr-2024

    Summary

    Go to the top of the page Help
    Symbol
    RPE65provided by CGNC
    Full Name
    RPE65, retinoid isomerohydrolaseprovided by CGNC
    Primary source
    CGNC:8554
    See related
    Ensembl:ENSGALG00010023506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 8
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 8 NC_052539.1 (28459714..28468361, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 8 NC_052580.1 (28471737..28480382, complement)

    Chromosome 8 - NC_052539.1Genomic Context describing neighboring genes Neighboring gene wntless Wnt ligand secretion mediator Neighboring gene microRNA 6653 Neighboring gene methylcrotonoyl-Coenzyme A carboxylase 2-like Neighboring gene DEP domain containing 1 Neighboring gene leucine rich repeat containing 7

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity. Nikolaeva O, et al. Biochem J, 2011 Jun 15. PMID 21446919
    2. Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane. Nikolaeva O, et al. FEBS J, 2009 Jun. PMID 19490105, Free PMC Article
    3. Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups. Yuan Q, et al. J Biol Chem, 2010 Jan 8. PMID 19892706, Free PMC Article
    4. RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye. Shyam R, et al. Proc Natl Acad Sci U S A, 2017 Oct 10. PMID 28874556, Free PMC Article
    5. Identification of key residues determining isomerohydrolase activity of human RPE65. Takahashi Y, et al. J Biol Chem, 2014 Sep 26. PMID 25112876, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RPE65 undergoes conformational changes in secondary and tertiary structures upon binding with the phospholipid membrane. These conformational rearrangements facilitate restoration of a catalytically active state of RPE65.
      Title: Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity.
    2. Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups.
      Title: Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups.
    3. Results provide conclusive evidence that RPE65 is the isomerohydrolase of the visual cycle.
      Title: Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane.
    4. RPE65 from the cone-dominant chicken RPE possesses significantly higher specific retinol isomerohydrolase activity, when compared with RPE65 from rod-dominant species
      Title: RPE65 from cone-dominant chicken is a more efficient isomerohydrolase compared with that from rod-dominant species.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables beta-carotene 15,15'-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables retinol isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in retinal metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in zeaxanthin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    retinoid isomerohydrolase
    Names
    all-trans-retinyl-palmitate hydrolase
    lutein isomerase
    meso-zeaxanthin isomerase
    retinal pigment epithelium-specific 65 kDa protein
    retinal pigment epithelium-specific protein 65kDa
    retinol isomerase
    NP_990215.1
    XP_015146455.1
    XP_040560441.1
    XP_040560442.1
    XP_046778292.1
    XP_046778293.1
    XP_046778294.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204884.2 → NP_990215.1  retinoid isomerohydrolase

      See identical proteins and their annotated locations for NP_990215.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000239
      UniProtKB/Swiss-Prot
      Q9YGX2
      UniProtKB/TrEMBL
      A0A8V0ZWQ7
      Related
      ENSGALP00010034815.1, ENSGALT00010057251.1
      Conserved Domains (1) summary
      pfam03055
      Location:21 → 530
      RPE65; Retinal pigment epithelial membrane protein

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      28459714..28468361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015290969.4 → XP_015146455.1  retinoid isomerohydrolase isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZWQ7
      Conserved Domains (1) summary
      pfam03055
      Location:20 → 561
      RPE65; Retinal pigment epithelial membrane protein

    2. XM_040704508.2 → XP_040560442.1  retinoid isomerohydrolase isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZN36, A0A8V1A0V9
      Related
      ENSGALP00010034818.1, ENSGALT00010057256.1
      Conserved Domains (1) summary
      cl10080
      Location:258 → 707
      RPE65; Retinal pigment epithelial membrane protein

    3. XM_040704507.2 → XP_040560441.1  retinoid isomerohydrolase isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZN36
      Conserved Domains (1) summary
      cl10080
      Location:258 → 738
      RPE65; Retinal pigment epithelial membrane protein

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      28471737..28480382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046922338.1 → XP_046778294.1  retinoid isomerohydrolase isoform X3

    2. XM_046922337.1 → XP_046778293.1  retinoid isomerohydrolase isoform X2

      UniProtKB/TrEMBL
      A0A8V1A0V9

    3. XM_046922336.1 → XP_046778292.1  retinoid isomerohydrolase isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9YGX2.1 GenPept UniProtKB/Swiss-Prot:Q9YGX2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous