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    rnf144b ring finger protein 144B [ Danio rerio (zebrafish) ]

    Gene ID: 394112, updated on 27-Mar-2024

    Summary

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    Official Symbol
    rnf144bprovided by ZNC
    Official Full Name
    ring finger protein 144Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1292
    See related
    Ensembl:ENSDARG00000024940 AllianceGenome:ZFIN:ZDB-GENE-040426-1292
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    IBRDC2; zgc:63907
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within protein ubiquitination. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in mitochondrial membrane. Orthologous to human RNF144B (ring finger protein 144B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (43368572..43392457)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (43464814..43488880)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zmp:0000000930 Neighboring gene coiled-coil domain containing 127a Neighboring gene mitochondrial ribosomal protein L32 Neighboring gene uncharacterized LOC110438000 Neighboring gene squalene epoxidase a Neighboring gene oxidation resistance 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression profiling and functional characterization of the duplicated Oxr1b gene in zebrafish. Xu H, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2021 Sep. PMID 34111665
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63907

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF144B
    NP_957431.2
    XP_005173584.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201137.2 → NP_957431.2  E3 ubiquitin-protein ligase RNF144B

      Status: PROVISIONAL

      Source sequence(s)
      BC053142
      UniProtKB/TrEMBL
      A0A8N7V037, Q7T3F2
      Related
      ENSDARP00000034051.6, ENSDART00000032778.6
      Conserved Domains (2) summary
      smart00647
      Location:101 → 166
      IBR; In Between Ring fingers
      pfam01485
      Location:185 → 225
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      43368572..43392457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173527.4 → XP_005173584.1  E3 ubiquitin-protein ligase RNF144B isoform X1

      UniProtKB/TrEMBL
      A0A8M2BKT1, F1R2U0, Q7T3F2
      Conserved Domains (1) summary
      pfam01485
      Location:101 → 160
      IBR; IBR domain, a half RING-finger domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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