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    CG10077 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38756, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG10077provided by FlyBase
    Primary source
    FLYBASE:FBgn0035720
    Locus tag
    Dmel_CG10077
    See related
    AllianceGenome:FB:FBgn0035720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:HL01868; BcDNA:HL07910; cg10077; Dmel\CG10077; DmRH5; p90
    Summary
    Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in RNA interference. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to several human genes including DDX17 (DEAD-box helicase 17). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CG10077 in Genome Data Viewer
    Location:
    65D3-65D4; 3-18 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6949491..6955904, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6942591..6949004, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45412 Neighboring gene target of wingless Neighboring gene uncharacterized protein Neighboring gene Ubiquinol-cytochrome c reductase complex assembly factor 1 Neighboring gene Surfeit 1 Neighboring gene sugarless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nascent-seq indicates widespread cotranscriptional RNA editing in Drosophila. Rodriguez J, et al. Mol Cell, 2012 Jul 13. PMID 22658416, Free PMC Article
    2. Diverse cell-specific patterns of alternative polyadenylation in Drosophila. Lee S, et al. Nat Commun, 2022 Sep 13. PMID 36100597, Free PMC Article
    3. Whole-genome analysis reveals that active heat shock factor binding sites are mostly associated with non-heat shock genes in Drosophila melanogaster. Gonsalves SE, et al. PLoS One, 2011 Jan 14. PMID 21264254, Free PMC Article
    4. Transcripts immunoprecipitated with Sxl protein in primordial germ cells of Drosophila embryos. Ota R, et al. Dev Growth Differ, 2017 Dec. PMID 29124738
    5. Tow (Target of Wingless), a novel repressor of the Hedgehog pathway in Drosophila. Ayers KL, et al. Dev Biol, 2009 May 15. PMID 19285058

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10077-PA
    CG10077-PC
    CG10077-PD
    NP_001261491.1
    NP_648062.2
    NP_729194.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6949491..6955904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139805.2 → NP_648062.2  uncharacterized protein Dmel_CG10077, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648062.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZI3, Q9VRZ5
      Related
      FBpp0076649
      Conserved Domains (3) summary
      cd00079
      Location:375 → 507
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:159 → 364
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      PTZ00110
      Location:49 → 544
      PTZ00110; helicase; Provisional

    2. NM_001274562.1 → NP_001261491.1  uncharacterized protein Dmel_CG10077, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261491.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZI3, Q9VRZ5
      Conserved Domains (3) summary
      cd00079
      Location:375 → 507
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:159 → 364
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      PTZ00110
      Location:49 → 544
      PTZ00110; helicase; Provisional

    3. NM_168182.3 → NP_729194.2  uncharacterized protein Dmel_CG10077, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729194.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU78
      Conserved Domains (3) summary
      smart00487
      Location:172 → 379
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:375 → 468
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:159 → 364
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KU78 Q7KU78
    Q8MRJ6 Q8MRJ6
    Q8MZI3 Q8MZI3
    Q8T0I3 Q8T0I3

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