myh6 myosin, heavy chain 6, cardiac muscle, alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myh6provided by ZNC
Official Full Name: myosin, heavy chain 6, cardiac muscle, alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031112-1
See related: Ensembl:ENSDARG00000090637 AllianceGenome:ZFIN:ZDB-GENE-031112-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: amhc; myhc6
Summary: Predicted to enable ATP binding activity; actin filament binding activity; and cytoskeletal motor activity. Acts upstream of or within heart contraction and heart development. Predicted to be part of myosin complex. Is expressed in cardiac muscle; heart primordium; heart rudiment; and pericardial region. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (53577498..53583436)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (53772081..53778019)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors present the adult cardiac phenotype of weak atrium, myh6-/-, which carry mutations in the zebrafish atrial myosin heavy chain.
Title: Ventricular remodeling of single-chambered myh6(-/-) adult zebrafish hearts occurs via a hyperplastic response and is accompanied by elastin deposition in the atrium.
Data show that an atrium-specific contractility defect due to mutation of the atrial myosin heavy chain has a profound impact on ventricular development.
Title: Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adult heart development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within atrial cardiac myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac atrium development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac atrium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac ventricle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle filament sliding	IBA Inferred from Biological aspect of Ancestor more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin-6

Names: atrial myosin heavy chain; cardiac muscle myosin heavy chain 6 alpha; myosin, heavy polypeptide 6, cardiac muscle, alpha; unm s459; unm_s459; wea; weak atrium

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198823.1 → NP_942118.1 myosin-6

See identical proteins and their annotated locations for NP_942118.1

Status: PROVISIONAL

Source sequence(s)

AY138982

UniProtKB/TrEMBL

Q6YJK1

Related

ENSDARP00000108536.1, ENSDART00000126983.3

Conserved Domains (8) summary

cd01377
Location:99 → 766

MYSc_class_II; class II myosins, motor domain

pfam00063
Location:87 → 766

Myosin_head; Myosin head (motor domain)

pfam01576
Location:846 → 1923

Myosin_tail_1; Myosin tail

pfam02736
Location:35 → 72

Myosin_N; Myosin N-terminal SH3-like domain

pfam07851
Location:1738 → 1833

TMPIT; TMPIT-like protein

cl12013
Location:1298 → 1490

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl19252
Location:1493 → 1578

MreC; rod shape-determining protein MreC

cl23720
Location:961 → 1094

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)