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    Hjurp Holliday junction recognition protein [ Mus musculus (house mouse) ]

    Gene ID: 381280, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hjurpprovided by MGI
    Official Full Name
    Holliday junction recognition proteinprovided by MGI
    Primary source
    MGI:MGI:2685821
    See related
    Ensembl:ENSMUSG00000044783 AllianceGenome:MGI:2685821
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm975; Mfleg1; 6430706D22Rik; A730008H23Rik; C330011F01Rik
    Summary
    Predicted to enable histone binding activity and identical protein binding activity. Predicted to be involved in several processes, including CENP-A containing chromatin assembly; regulation of DNA binding activity; and regulation of protein-containing complex assembly. Located in chromosome, centromeric region. Is expressed in several structures, including blastocyst; early embryo; extraembryonic component; and neural retina. Orthologous to human HJURP (Holliday junction recognition protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 46.1), CNS E11.5 (RPKM 40.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hjurp in Genome Data Viewer
    Location:
    1; 1 D
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (88186578..88205366, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (88258856..88277644, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A9 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6B Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6A Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A5 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90112870-90113171 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90113610-90113910 Neighboring gene STARR-seq mESC enhancer starr_01629 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90118277-90118578 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene STARR-positive B cell enhancer mm9_chr1:90185502-90185802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90186563-90186863 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90195708-90196009 Neighboring gene transient receptor potential cation channel, subfamily M, member 8 Neighboring gene STARR-seq mESC enhancer starr_01631 Neighboring gene secreted phosphoprotein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Divergence patterns of genic copy number variation in natural populations of the house mouse (Mus musculus domesticus) reveal three conserved genes with major population-specific expansions. Pezer Ž, et al. Genome Res, 2015 Aug. PMID 26149421, Free PMC Article
    2. Roles of Mis18α in epigenetic regulation of centromeric chromatin and CENP-A loading. Kim IS, et al. Mol Cell, 2012 May 11. PMID 22516971
    3. Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation. Walcher T, et al. Development, 2013 Mar. PMID 23404109, Free PMC Article
    4. Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models. Dorval V, et al. PLoS One, 2014. PMID 24427314, Free PMC Article
    5. AP-2δ is a crucial transcriptional regulator of the posterior midbrain. Hesse K, et al. PLoS One, 2011. PMID 21858141, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study showed major differences in gene copy number in natural populations. CWC22, SFI1, and HJURP are highly conserved genes with the most copy-number variation. They all exhibit population-specific expansion patterns, perhaps for local adaptations.
      Title: Divergence patterns of genic copy number variation in natural populations of the house mouse (Mus musculus domesticus) reveal three conserved genes with major population-specific expansions.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC66590

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CENP-A containing chromatin assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Holliday junction recognition protein
    Names
    fetal liver expressing gene 1 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198652.2 → NP_941054.2  Holliday junction recognition protein

      Status: VALIDATED

      Source sequence(s)
      AC087780, AK164562, BC057309, CJ241667
      Consensus CDS
      CCDS15144.1
      UniProtKB/Swiss-Prot
      Q6BCZ4, Q6PG16, Q8C9A7
      UniProtKB/TrEMBL
      E9QKG8
      Related
      ENSMUSP00000054263.9, ENSMUST00000054674.15
      Conserved Domains (3) summary
      pfam10384
      Location:11 → 68
      Scm3; Centromere protein Scm3
      pfam12346
      Location:254 → 370
      HJURP_mid; Holliday junction recognition protein-associated repeat
      pfam12347
      Location:386 → 444
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      88186578..88205366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529721.5 → XP_006529784.1  Holliday junction recognition protein isoform X2

      UniProtKB/Swiss-Prot
      Q6BCZ4, Q6PG16, Q8C9A7
      UniProtKB/TrEMBL
      E9Q4T0
      Related
      ENSMUSP00000070419.6, ENSMUST00000065420.12
      Conserved Domains (3) summary
      pfam10384
      Location:11 → 68
      Scm3; Centromere protein Scm3
      pfam12346
      Location:178 → 294
      HJURP_mid; Holliday junction recognition protein-associated repeat
      pfam12347
      Location:309 → 367
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    2. XM_006529720.4 → XP_006529783.1  Holliday junction recognition protein isoform X1

      See identical proteins and their annotated locations for XP_006529783.1

      UniProtKB/Swiss-Prot
      Q6BCZ4, Q6PG16, Q8C9A7
      Conserved Domains (3) summary
      pfam10384
      Location:11 → 68
      Scm3; Centromere protein Scm3
      pfam12346
      Location:254 → 353
      HJURP_mid; Holliday junction recognition protein-associated repeat
      pfam12347
      Location:368 → 426
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    3. XM_006529722.5 → XP_006529785.1  Holliday junction recognition protein isoform X3

      UniProtKB/Swiss-Prot
      Q6BCZ4, Q6PG16, Q8C9A7
      Conserved Domains (2) summary
      pfam12346
      Location:148 → 264
      HJURP_mid; Holliday junction recognition protein-associated repeat
      pfam12347
      Location:279 → 337
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PG16.1 GenPept UniProtKB/Swiss-Prot:Q6PG16

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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