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    DFFB DNA fragmentation factor subunit beta [ Gallus gallus (chicken) ]

    Gene ID: 374158, updated on 5-Mar-2024

    Summary

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    Symbol
    DFFBprovided by CGNC
    Full Name
    DNA fragmentation factor subunit betaprovided by CGNC
    Primary source
    CGNC:645
    See related
    Ensembl:ENSGALG00010021223
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 21 NC_052552.1 (898392..912433, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 21 NC_052593.1 (930073..944114, complement)

    Chromosome 21 - NC_052552.1Genomic Context describing neighboring genes Neighboring gene adherens junctions associated protein 1 Neighboring gene uncharacterized LOC121107368 Neighboring gene C1orf174 homolog Neighboring gene centrosomal protein 104 Neighboring gene leucine rich repeat containing 47

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CAD/DFF40 nuclease is dispensable for high molecular weight DNA cleavage and stage I chromatin condensation in apoptosis. Samejima K, et al. J Biol Chem, 2001 Nov 30. PMID 11577114
    2. Coordinated and sequential activation of neutral and acidic DNases during interdigital cell death in the embryonic limb. Montero JA, et al. Apoptosis, 2010 Oct. PMID 20614251

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA fragmentation factor subunit beta
    Names
    DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204285.2 → NP_989616.1  DNA fragmentation factor subunit beta

      See identical proteins and their annotated locations for NP_989616.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000329
      UniProtKB/TrEMBL
      Q8UVS5
      Related
      ENSGALP00010030627.1, ENSGALT00010051436.1
      Conserved Domains (2) summary
      cd06535
      Location:4 → 80
      CIDE_N_CAD; CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are ...
      pfam09230
      Location:100 → 324
      DFF40; DNA fragmentation factor 40 kDa

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      898392..912433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015296808.4 → XP_015152294.2  DNA fragmentation factor subunit beta isoform X2

      Conserved Domains (1) summary
      cl02541
      Location:4 → 80
      CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...

    2. XM_015296807.4 → XP_015152293.2  DNA fragmentation factor subunit beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZPI3
      Related
      ENSGALP00010030632.1, ENSGALT00010051441.1
      Conserved Domains (1) summary
      cl02541
      Location:4 → 80
      CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...

    3. XM_040651092.2 → XP_040507026.2  DNA fragmentation factor subunit beta isoform X3

    4. XM_046903096.1 → XP_046759052.1  DNA fragmentation factor subunit beta isoform X4

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052593.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      930073..944114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046931120.1 → XP_046787076.1  DNA fragmentation factor subunit beta isoform X2

    2. XM_046931119.1 → XP_046787075.1  DNA fragmentation factor subunit beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZPI3

    3. XM_046931121.1 → XP_046787077.1  DNA fragmentation factor subunit beta isoform X3

    4. XM_046931122.1 → XP_046787078.1  DNA fragmentation factor subunit beta isoform X4

    Nucleotide Protein
    Heading Accession and Version

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