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    PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 [ Gallus gallus (chicken) ]

    Gene ID: 374030, updated on 5-Mar-2024

    Summary

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    Symbol
    PCBD2provided by CGNC
    Full Name
    pterin-4 alpha-carbinolamine dehydratase 2provided by CGNC
    Primary source
    CGNC:4793
    See related
    Ensembl:ENSGALG00010013121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    DCOHM
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 13 NC_052544.1 (15253395..15270757, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 13 NC_052585.1 (15265229..15282591, complement)

    Chromosome 13 - NC_052544.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121106745 Neighboring gene uncharacterized LOC107054563 Neighboring gene paired like homeodomain 1 Neighboring gene uncharacterized LOC107054562 Neighboring gene thioredoxin domain containing 15 Neighboring gene C5orf24 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential expression of chicken dimerization cofactor of hepatocyte nuclear factor-1 (DcoH) and its novel counterpart, DcoHalpha. Kim H, et al. Biochem J, 2001 Mar 15. PMID 11237869, Free PMC Article
    2. ESTs from brain and testis of White Leghorn and red junglefowl: annotation, bioinformatic classification of unknown transcripts and analysis of expression levels. Savolainen P, et al. Cytogenet Genome Res, 2005. PMID 16093725
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tetrahydrobiopterin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pterin-4-alpha-carbinolamine dehydratase 2
    Names
    4-alpha-hydroxy-tetrahydropterin dehydratase 2
    6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
    DCoH-alpha
    PHS 2
    dcoH-like protein DCoHm
    dimerization cofactor of hepatocyte nuclear factor 1 (HNF1) from muscle
    pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
    NP_989534.2
    XP_015149470.2
    XP_025010548.1
    XP_046782700.1
    XP_046782701.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204203.3 → NP_989534.2  pterin-4-alpha-carbinolamine dehydratase 2

      Status: VALIDATED

      Source sequence(s)
      AF190051, BX275431, CN224897, HAEK01112718, JAENSK010000256
      Related
      ENSGALP00010018362.1, ENSGALT00010031453.1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      15253395..15270757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015293984.3 → XP_015149470.2  pterin-4-alpha-carbinolamine dehydratase 2 isoform X1

      Conserved Domains (1) summary
      cl00942
      Location:1 → 55
      PCD_DCoH; The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating ...

    2. XM_025154780.2 → XP_025010548.1  pterin-4-alpha-carbinolamine dehydratase 2 isoform X2

      Conserved Domains (1) summary
      cl00942
      Location:1 → 50
      PCD_DCoH; The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating ...

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      15265229..15282591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046926744.1 → XP_046782700.1  pterin-4-alpha-carbinolamine dehydratase 2 isoform X1

      Conserved Domains (1) summary
      cl00942
      Location:1 → 55
      PCD_DCoH; The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating ...

    2. XM_046926745.1 → XP_046782701.1  pterin-4-alpha-carbinolamine dehydratase 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DG45.1 GenPept UniProtKB/Swiss-Prot:Q9DG45

    Gene LinkOut

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