ccnb2 cyclin B2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ccnb2provided by ZNC
Official Full Name: cyclin B2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030429-12
See related: Ensembl:ENSDARG00000036180 AllianceGenome:ZFIN:ZDB-GENE-030429-12
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb303
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in centrosome; cytoplasm; and nucleus. Is expressed in gonad; nervous system; pharyngeal arch 3-7 skeleton; and proliferative region. Orthologous to human CCNB2 (cyclin B2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (30626418..30631119)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (30355278..30359969)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

intestinal clock controls the expression of key cell cycle regulators, such as cdc2, wee1, p21, PCNA and cdk2, but only weakly influences cyclin B1, cyclin B2 and cyclin E1 expression.
Title: Circadian clock regulation of the cell cycle in the zebrafish intestine.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle phase transition	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G2/mitotic-specific cyclin-B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199430.1 → NP_955462.1 G2/mitotic-specific cyclin-B2

See identical proteins and their annotated locations for NP_955462.1

Status: PROVISIONAL

Source sequence(s)

BC045937

UniProtKB/TrEMBL

Q7ZVA8

Related

ENSDARP00000052540.4, ENSDART00000052541.6

Conserved Domains (2) summary

pfam00134
Location:125 → 250

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:252 → 370

Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

30626418..30631119

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005168860.4 → XP_005168917.1 G2/mitotic-specific cyclin-B2 isoform X1

UniProtKB/TrEMBL

A0A8M2BG43

Conserved Domains (2) summary

pfam00134
Location:124 → 249

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:251 → 369

Cyclin_C; Cyclin, C-terminal domain