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    Tsacc TSSK6 activating co-chaperone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361979, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tsaccprovided by RGD
    Official Full Name
    TSSK6 activating co-chaperoneprovided by RGD
    Primary source
    RGD:1304953
    See related
    Ensembl:ENSRNOG00000037552 AllianceGenome:RGD:1304953
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304953
    Summary
    Predicted to enable chaperone binding activity. Predicted to be active in cytoplasm. Orthologous to human TSACC (TSSK6 activating cochaperone). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 734.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176053672..176063412, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173755841..173765564, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187659103..187668781, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene Rh family B glycoprotein Neighboring gene uncharacterized LOC103691617 Neighboring gene chaperonin containing TCP1 subunit 3 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene ATP synthase subunit g, mitochondrial pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinase. Jha KN, et al. J Biol Chem, 2010 Nov 5. PMID 20829357, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TSSK6-activating co-chaperone protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108556.1 → NP_001102026.1  TSSK6-activating co-chaperone protein

      See identical proteins and their annotated locations for NP_001102026.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473976
      UniProtKB/TrEMBL
      A6J660, D3ZH74
      Related
      ENSRNOP00000053736.2, ENSRNOT00000056898.4
      Conserved Domains (1) summary
      pfam15836
      Location:1 → 125
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176053672..176063412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761180.4 → XP_008759402.1  TSSK6-activating co-chaperone protein isoform X1

      See identical proteins and their annotated locations for XP_008759402.1

      UniProtKB/TrEMBL
      A6J660, D3ZH74
      Conserved Domains (1) summary
      pfam15836
      Location:1 → 125
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    2. XM_006232690.5 → XP_006232752.1  TSSK6-activating co-chaperone protein isoform X1

      See identical proteins and their annotated locations for XP_006232752.1

      UniProtKB/TrEMBL
      A6J660, D3ZH74
      Conserved Domains (1) summary
      pfam15836
      Location:1 → 125
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    3. XM_063282123.1 → XP_063138193.1  TSSK6-activating co-chaperone protein isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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