Usp19 ubiquitin specific peptidase 19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Usp19provided by RGD
Official Full Name: ubiquitin specific peptidase 19provided by RGD
Primary source: RGD:1303276
See related: Ensembl:ENSRNOG00000049531 AllianceGenome:RGD:1303276
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Hsp90 protein binding activity; deubiquitinase activity; and ubiquitin protein ligase binding activity. Involved in positive regulation of cell cycle process; protein deubiquitination; and regulation of protein stability. Predicted to be located in cytosol and endoplasmic reticulum membrane. Orthologous to human USP19 (ubiquitin specific peptidase 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 264.0), Adrenal (RPKM 244.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (118069227..118080283)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (109190727..109201761)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (117280690..117291729)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ubiquitin-specific protease 19 blunts pathological cardiac hypertrophy via inhibition of the TAK1-dependent pathway.
Title: Ubiquitin-specific protease 19 blunts pathological cardiac hypertrophy via inhibition of the TAK1-dependent pathway.
High iodine intake had no discernible effects on USP20. Temporary increases in USP33 and USP19 mRNA levels were observed. The enzymes related to D2 ubiquitination change with prolonged high iodine intake. Increased D2 ubiquitination suppresses the activity of D2, causing a decrease in negative feedback of the hypothalamic-pituitary-thyroid axis.
Title: Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary.
Deubiquitination by USP19 does modulate muscle cell differentiation and that this function requires the ER-localized isoform and appears to act through regulation of the unfolded-protein response (UPR) signaling.
Title: USP19 deubiquitinating enzyme inhibits muscle cell differentiation by suppressing unfolded-protein response signaling.
USP19 modulates transcription of major myofibrillar proteins.
Title: USP19-deubiquitinating enzyme regulates levels of major myofibrillar proteins in L6 muscle cells.
study reports that the USP19 deubiquitinating enzyme interacts with and stabilizes KPC1, thereby modulating p27(Kip1) levels and cell proliferation
Title: USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1.
USP19 is regulated in rat skeletal muscle during catabolic states.
Title: USP19 is a ubiquitin-specific protease regulated in rat skeletal muscle during catabolic states.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables K48-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of skeletal muscle tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell cycle process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein stability	IDA Inferred from Direct Assay more info	PubMed
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 19

Names: deubiquitinating enzyme 19; ubiquitin specific protease 19; ubiquitin thioesterase 19; ubiquitin thiolesterase 19; ubiquitin-specific-processing protease 19

NP_001001516.1

EC 3.4.19.12

XP_006243855.1

EC 3.4.19.12

XP_006243856.1

EC 3.4.19.12

XP_006243857.1

EC 3.4.19.12

XP_006243858.1

EC 3.4.19.12

XP_006243859.1

EC 3.4.19.12

XP_006243860.1

EC 3.4.19.12

XP_006243861.1

EC 3.4.19.12

XP_038937619.1

EC 3.4.19.12

XP_038937620.1

EC 3.4.19.12

XP_063121747.1

EC 3.4.19.12

XP_063121748.1

EC 3.4.19.12

XP_063121749.1

EC 3.4.19.12

XP_063121750.1

EC 3.4.19.12

XP_063121751.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001516.2 → NP_001001516.1 ubiquitin carboxyl-terminal hydrolase 19

See identical proteins and their annotated locations for NP_001001516.1

Status: PROVISIONAL

Source sequence(s)

AY605065

UniProtKB/Swiss-Prot

Q6J1Y9

UniProtKB/TrEMBL

M0RDN9

Conserved Domains (7) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:327 → 423

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

cd02674
Location:1094 → 1251

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:537 → 723

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam01753
Location:830 → 872

zf-MYND; MYND finger

pfam14533
Location:737 → 793

USP7_C2; Ubiquitin-specific protease C-terminal

pfam16602
Location:414 → 534

USP19_linker; Linker region of USP19 deubiquitinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

118069227..118080283

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243797.5 → XP_006243859.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X8

See identical proteins and their annotated locations for XP_006243859.1

UniProtKB/TrEMBL

A0A8I5ZMS3, A6I360

Related

ENSRNOP00000069554.2

Conserved Domains (7) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:327 → 423

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

cd02674
Location:1096 → 1253

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:539 → 725

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam01753
Location:832 → 874

zf-MYND; MYND finger

pfam14533
Location:739 → 795

USP7_C2; Ubiquitin-specific protease C-terminal

pfam16602
Location:414 → 536

USP19_linker; Linker region of USP19 deubiquitinase
XM_006243799.5 → XP_006243861.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X10

UniProtKB/TrEMBL

A0A8I5ZMS3

Conserved Domains (7) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:327 → 423

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

cd02674
Location:1094 → 1251

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:537 → 723

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam01753
Location:830 → 872

zf-MYND; MYND finger

pfam14533
Location:737 → 793

USP7_C2; Ubiquitin-specific protease C-terminal

pfam16602
Location:414 → 534

USP19_linker; Linker region of USP19 deubiquitinase
XM_006243798.5 → XP_006243860.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X9

UniProtKB/TrEMBL

A0A8I5ZMS3

Related

ENSRNOP00000078495.1

Conserved Domains (7) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:326 → 422

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

cd02674
Location:1095 → 1252

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:538 → 724

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam01753
Location:831 → 873

zf-MYND; MYND finger

pfam14533
Location:738 → 794

USP7_C2; Ubiquitin-specific protease C-terminal

pfam16602
Location:413 → 535

USP19_linker; Linker region of USP19 deubiquitinase
XM_039081692.2 → XP_038937620.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X11

UniProtKB/TrEMBL

A0A8I5ZMS3

Conserved Domains (4) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:326 → 422

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

COG5560
Location:531 → 1253

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

pfam16602
Location:413 → 533

USP19_linker; Linker region of USP19 deubiquitinase
XM_063265679.1 → XP_063121749.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X12

UniProtKB/TrEMBL

A0A0G2JVN4
XM_063265681.1 → XP_063121751.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X14
XM_063265680.1 → XP_063121750.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X13
XM_006243793.5 → XP_006243855.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X1

See identical proteins and their annotated locations for XP_006243855.1

UniProtKB/TrEMBL

A6I361, M0RDN9

Conserved Domains (7) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:327 → 423

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

cd02674
Location:1096 → 1253

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:539 → 725

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam01753
Location:832 → 874

zf-MYND; MYND finger

pfam14533
Location:739 → 795

USP7_C2; Ubiquitin-specific protease C-terminal

pfam16602
Location:414 → 536

USP19_linker; Linker region of USP19 deubiquitinase
XM_006243795.5 → XP_006243857.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X3

UniProtKB/TrEMBL

M0RDN9

Related

ENSRNOP00000067744.2

Conserved Domains (7) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:327 → 423

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

cd02674
Location:1094 → 1251

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:537 → 723

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam01753
Location:830 → 872

zf-MYND; MYND finger

pfam14533
Location:737 → 793

USP7_C2; Ubiquitin-specific protease C-terminal

pfam16602
Location:414 → 534

USP19_linker; Linker region of USP19 deubiquitinase
XM_006243794.5 → XP_006243856.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X2

UniProtKB/TrEMBL

M0RDN9

Conserved Domains (4) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:326 → 422

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

COG5560
Location:533 → 1255

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

pfam16602
Location:413 → 535

USP19_linker; Linker region of USP19 deubiquitinase
XM_039081691.2 → XP_038937619.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X4

UniProtKB/TrEMBL

M0RDN9

Conserved Domains (4) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:326 → 422

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

COG5560
Location:531 → 1253

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

pfam16602
Location:413 → 533

USP19_linker; Linker region of USP19 deubiquitinase
XM_006243796.5 → XP_006243858.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X5

UniProtKB/TrEMBL

A0A8I6AF46, M0RDN9

Related

ENSRNOP00000090860.1

Conserved Domains (7) summary

cd06463
Location:50 → 132

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:319 → 415

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

cd02674
Location:1088 → 1245

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:531 → 717

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam01753
Location:824 → 866

zf-MYND; MYND finger

pfam14533
Location:731 → 787

USP7_C2; Ubiquitin-specific protease C-terminal

pfam16602
Location:406 → 528

USP19_linker; Linker region of USP19 deubiquitinase
XM_063265678.1 → XP_063121748.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X7
XM_063265677.1 → XP_063121747.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X6