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    Mob3 MOB kinase activator 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34372, updated on 27-Mar-2024

    Summary

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    Official Symbol
    Mob3provided by FlyBase
    Official Full Name
    MOB kinase activator 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0259482
    Locus tag
    Dmel_CG4946
    See related
    AllianceGenome:FB:FBgn0259482
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4946; Dmel\CG4946; dmob3; Dmob3; DMob3
    Summary
    Predicted to enable protein kinase activator activity and protein kinase binding activity. Predicted to be involved in positive regulation of protein phosphorylation and signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in organism. Orthologous to human MOB3A (MOB kinase activator 3A); MOB3B (MOB kinase activator 3B); and MOB3C (MOB kinase activator 3C). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Mob3 in Genome Data Viewer
    Location:
    31B1-31B1; 2-40 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10265336..10266570)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10265336..10266570)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Repressor splicing factor 1 Neighboring gene REPTOR-binding partner Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Mob family proteins interact with the related tricornered (Trc) and warts (Wts) kinases. He Y, et al. Mol Biol Cell, 2005 Sep. PMID 15975907, Free PMC Article
    2. DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization. Schulte J, et al. J Neurosci, 2010 Apr 14. PMID 20392941, Free PMC Article
    3. The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases. Bannan BA, et al. Fly (Austin), 2008 Jul-Aug. PMID 18719403, Free PMC Article
    4. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MOB kinase activator 3
    Names
    CG4946-PA
    Mob3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10265336..10266570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135520.4 → NP_609364.1  MOB kinase activator 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609364.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VL13
      Related
      FBpp0079573
      Conserved Domains (1) summary
      pfam03637
      Location:36 → 208
      Mob1_phocein; Mob1/phocein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL13.1 Q9VL13

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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