slc1a2b solute carrier family 1 member 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc1a2bprovided by ZNC
Official Full Name: solute carrier family 1 member 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7779
See related: Ensembl:ENSDARG00000102453 AllianceGenome:ZFIN:ZDB-GENE-030131-7779
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: eaat2; slc1a2; fj34b12; zgc:65897; wu:fj34b12
Summary: Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neutral amino acid transmembrane transporter activity. Acts upstream of or within larval locomotory behavior. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in nervous system and spinal cord neural tube. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (37366698..37407757)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (36796139..36837199)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity.
Title: Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity.
This work demonstrates Shaping of Signal Transmission at the Photoreceptor Synapse by EAAT2 Glutamate Transporters.
Title: Shaping of Signal Transmission at the Photoreceptor Synapse by EAAT2 Glutamate Transporters.
Disruption of Eaat2b, a glutamate transporter, results in abnormal motor behaviors in developing zebrafish.
Title: Disruption of Eaat2b, a glutamate transporter, results in abnormal motor behaviors in developing zebrafish.

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General gene information

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Markers

fj50f11.y1 (e-PCR)
- UniSTS:199478

fj37e10.y1 (e-PCR)
- UniSTS:199237

fj34b12.x1 (e-PCR)
- UniSTS:199147

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-aspartate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-glutamate import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of glutamate uptake involved in transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: excitatory amino acid transporter 2; excitatory amino acid transporter 2b

Names: EAAT2a; SLC1A2a; solute carrier family 1 (glial high affinity glutamate transporter), member 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2b; tnt

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.