Pon2 paraoxonase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pon2provided by MGI
Official Full Name: paraoxonase 2provided by MGI
Primary source: MGI:MGI:106687
See related: Ensembl:ENSMUSG00000032667 AllianceGenome:MGI:106687
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6330405I24Rik
Summary: Predicted to enable arylesterase activity and identical protein binding activity. Predicted to be involved in aromatic compound catabolic process and response to toxic substance. Predicted to be located in several cellular components, including lysosome; mitochondrion; and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; neurodegenerative disease (multiple); type 2 diabetes mellitus; and vascular dementia. Orthologous to human PON2 (paraoxonase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 37.9), liver E14 (RPKM 21.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 1.99 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (5264620..5298408, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (5264620..5298345, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis.
Title: Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis.
Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling.
Title: Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling.
Examining the role of paraoxonase 2 in the dopaminergic system of the mouse brain.
Title: Examining the role of paraoxonase 2 in the dopaminergic system of the mouse brain.
Paraoxonase 2 is an ER chaperone that regulates the epithelial Na(+) channel.
Title: Paraoxonase 2 is an ER chaperone that regulates the epithelial Na(+) channel.
Paraoxonase 2 deficiency in mice alters motor behavior and causes region-specific transcript changes in the brain.
Title: Paraoxonase 2 deficiency in mice alters motor behavior and causes region-specific transcript changes in the brain.
Paraoxonase 2 protects against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by enhancing Nrf2 activation via GSK-3beta modulation.
Title: Paraoxonase 2 protects against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by enhancing Nrf2 activation via GSK-3β modulation.
Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis.
Title: Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis.
PON2 protects against acute myocardial ischemia-reperfusion injury by reducing mitochondrial dysfunction and oxidative stress in cardiomyocytes.
Title: Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway.
suggesting that PON2 is necessary for proper mitochondrial function
Title: Paraoxonase 2 prevents the development of heart failure.
PON-2 regulates ENaC activity by modulating its intracellular trafficking and surface expression
Title: Regulation of the epithelial Na(+) channel by paraoxonase-2.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

Pon2 (e-PCR), detects polymorphism
- UniSTS:273728

Pon2 (e-PCR), detects polymorphism
- UniSTS:144239

Pon2 (e-PCR), detects polymorphism
- UniSTS:144240

AI481612 (e-PCR)
- UniSTS:179333

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyl-L-homoserine-lactone lactonohydrolase activity	IEA Inferred from Electronic Annotation more info
enables arylesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aromatic compound catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serum paraoxonase/arylesterase 2

Names: A-esterase 2; aromatic esterase 2; serum aryldialkylphosphatase 2

NP_899131.1

EC 3.1.1.2

EC 3.1.1.81

XP_006505185.1

EC 3.1.1.2

EC 3.1.1.81

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183308.3 → NP_899131.1 serum paraoxonase/arylesterase 2

See identical proteins and their annotated locations for NP_899131.1

Status: VALIDATED

Source sequence(s)

AC023285, AC164289

Consensus CDS

CCDS19900.1

UniProtKB/Swiss-Prot

Q3TAD3, Q62086, Q8CFK3

Related

ENSMUSP00000062670.9, ENSMUST00000057792.9

Conserved Domains (1) summary

pfam01731
Location:167 → 252

Arylesterase; Arylesterase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

5264620..5298408 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505122.3 → XP_006505185.1 serum paraoxonase/arylesterase 2 isoform X1

Conserved Domains (2) summary

pfam01731
Location:81 → 166

Arylesterase

pfam08450
Location:125 → 210

SGL; SMP-30/Gluconolaconase/LRE-like region