Abi2 abl interactor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abi2provided by MGI
Official Full Name: abl interactor 2provided by MGI
Primary source: MGI:MGI:106913
See related: Ensembl:ENSMUSG00000026782 AllianceGenome:MGI:106913
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AblBP3; ArgBP1; C130078H13; 8430425M24Rik
Summary: Predicted to enable several functions, including SH3 domain binding activity; identical protein binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to small GTPase binding activity. Involved in lens fiber cell morphogenesis; postsynaptic actin cytoskeleton organization; and regulation of dendritic spine morphogenesis. Acts upstream of or within several processes, including camera-type eye development; dendrite development; and learning or memory. Located in adherens junction; dendrite; and glutamatergic synapse. Is active in dendritic spine and postsynaptic actin cytoskeleton. Is expressed in several structures, including fronto-nasal process; future brain; intestine smooth muscle circular layer; nervous system; and trunk. Orthologous to human ABI2 (abl interactor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in frontal lobe adult (RPKM 18.9), CNS E18 (RPKM 17.1) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C2; 1 30.47 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (60444927..60521104)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (60405768..60481945)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated that WAVE2-Abi2 complex, which controls growth cone activity, is crucial for completing transition from a multipolar to bipolar shape.
Title: WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration.
TRIM32 is a novel oncogene that promotes tumor growth, metastasis, and resistance to anticancer drugs via degradation of Abl-interactor 2
Title: Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.
findings support a role for Abi2 in the regulation of cytoskeletal dynamics at adherens junctions and dendritic spines, which is critical for intercellular connectivity, cell morphogenesis, and cognitive functions
Title: ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory.
NESH (Abi-3), like Abi-1 and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl.
Title: NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI839867 (e-PCR)
- UniSTS:164118

NoName (e-PCR)
- UniSTS:234142

Abi2 (e-PCR), detects polymorphism
- UniSTS:532413

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IBA Inferred from Biological aspect of Ancestor more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables proline-rich region binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
contributes_to small GTPase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lens fiber cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zonula adherens assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCAR complex	ISO Inferred from Sequence Orthology more info
colocalizes_with actin filament	ISO Inferred from Sequence Orthology more info
is_active_in actin-based cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium tip	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: abl interactor 2

Names: abelson interactor 2; abi-2; abl-binding protein 3; arg-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198570.2 → NP_001185499.1 abl interactor 2 isoform 1

See identical proteins and their annotated locations for NP_001185499.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC158969

Consensus CDS

CCDS78593.1

UniProtKB/TrEMBL

Q6AXD2

Related

ENSMUSP00000140274.2, ENSMUST00000188618.7

Conserved Domains (2) summary

pfam07815
Location:93 → 169

Abi_HHR; Abl-interactor HHR

cl17036
Location:452 → 486

SH3; Src Homology 3 domain superfamily
NM_001198571.2 → NP_001185500.1 abl interactor 2 isoform 2

See identical proteins and their annotated locations for NP_001185500.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AC158969

Consensus CDS

CCDS78594.1

UniProtKB/TrEMBL

Q6AXH6

Related

ENSMUSP00000141068.2, ENSMUST00000189980.7

Conserved Domains (2) summary

cd11972
Location:419 → 479

SH3_Abi2; Src homology 3 domain of Abl Interactor 2

pfam07815
Location:93 → 169

Abi_HHR; Abl-interactor HHR
NM_001404705.1 → NP_001391634.1 abl interactor 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC158969
NM_001404706.1 → NP_001391635.1 abl interactor 2 isoform 5

Status: VALIDATED

Source sequence(s)

AC158969
NM_001404707.1 → NP_001391636.1 abl interactor 2 isoform 6

Status: VALIDATED

Source sequence(s)

AC158969
NM_001404708.1 → NP_001391637.1 abl interactor 2 isoform 7

Status: VALIDATED

Source sequence(s)

AC158969
NM_001404709.1 → NP_001391638.1 abl interactor 2 isoform 8

Status: VALIDATED

Source sequence(s)

AC158969
NM_001404710.1 → NP_001391639.1 abl interactor 2 isoform 9

Status: VALIDATED

Source sequence(s)

AC158969
NM_001404711.1 → NP_001391640.1 abl interactor 2 isoform 10

Status: VALIDATED

Source sequence(s)

AC158969
NM_001404712.1 → NP_001391641.1 abl interactor 2 isoform 11

Status: VALIDATED

Source sequence(s)

AC158969
NM_001404713.1 → NP_001391642.1 abl interactor 2 isoform 12

Status: VALIDATED

Source sequence(s)

AC158969

UniProtKB/TrEMBL

A0A087WPP8

Related

ENSMUSP00000139867.2, ENSMUST00000187709.7
NM_001404714.1 → NP_001391643.1 abl interactor 2 isoform 13

Status: VALIDATED

Source sequence(s)

AC158969
NM_001404715.1 → NP_001391644.1 abl interactor 2 isoform 14

Status: VALIDATED

Source sequence(s)

AC158969
NM_001404716.1 → NP_001391645.1 abl interactor 2 isoform 15

Status: VALIDATED

Source sequence(s)

AC158969
NM_001404717.1 → NP_001391646.1 abl interactor 2 isoform 16

Status: VALIDATED

Source sequence(s)

AC158969
NM_001404718.1 → NP_001391647.1 abl interactor 2 isoform 17

Status: VALIDATED

Source sequence(s)

AC158969
NM_001404719.1 → NP_001391648.1 abl interactor 2 isoform 18

Status: VALIDATED

Source sequence(s)

AC158969
NM_001404720.1 → NP_001391649.1 abl interactor 2 isoform 19

Status: VALIDATED

Source sequence(s)

AC158969
NM_001404721.1 → NP_001391650.1 abl interactor 2 isoform 20

Status: VALIDATED

Source sequence(s)

AC158969
NM_198127.3 → NP_937760.1 abl interactor 2 isoform 3

See identical proteins and their annotated locations for NP_937760.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.

Source sequence(s)

AC158969

Consensus CDS

CCDS14991.1

UniProtKB/Swiss-Prot

P62484

Related

ENSMUSP00000058754.9, ENSMUST00000052332.15

Conserved Domains (2) summary

cd11972
Location:385 → 445

SH3_Abi2; Src homology 3 domain of Abl Interactor 2

pfam07815
Location:93 → 163

Abi_HHR; Abl-interactor HHR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

60444927..60521104

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496080.4 → XP_006496143.1 abl interactor 2 isoform X13

Conserved Domains (2) summary

cd11972
Location:420 → 480

SH3_Abi2; Src homology 3 domain of Abl Interactor 2

pfam07815
Location:93 → 169

Abi_HHR; Abl-interactor HHR
XM_006496085.4 → XP_006496148.1 abl interactor 2 isoform X21

Conserved Domains (2) summary

cd11972
Location:391 → 451

SH3_Abi2; Src homology 3 domain of Abl Interactor 2

pfam07815
Location:93 → 169

Abi_HHR; Abl-interactor HHR
XM_017321240.2 → XP_017176729.1 abl interactor 2 isoform X2

Conserved Domains (3) summary

cd11972
Location:480 → 540

SH3_Abi2; Src homology 3 domain of Abl Interactor 2

PHA03247
Location:199 → 414

PHA03247; large tegument protein UL36; Provisional

pfam07815
Location:93 → 169

Abi_HHR; Abl-interactor HHR
XM_036165783.1 → XP_036021676.1 abl interactor 2 isoform X14

Conserved Domains (2) summary

cd11972
Location:419 → 479

SH3_Abi2; Src homology 3 domain of Abl Interactor 2

pfam07815
Location:93 → 156

Abi_HHR; Abl-interactor HHR
XM_036165799.1 → XP_036021692.1 abl interactor 2 isoform X24

Conserved Domains (2) summary

cd11972
Location:371 → 431

SH3_Abi2; Src homology 3 domain of Abl Interactor 2

pfam07815
Location:93 → 156

Abi_HHR; Abl-interactor HHR
XM_030255006.1 → XP_030110866.1 abl interactor 2 isoform X4

Conserved Domains (3) summary

cd11972
Location:474 → 534

SH3_Abi2; Src homology 3 domain of Abl Interactor 2

PHA03247
Location:263 → 399

PHA03247; large tegument protein UL36; Provisional

pfam07815
Location:93 → 163

Abi_HHR; Abl-interactor HHR
XM_030255012.1 → XP_030110872.1 abl interactor 2 isoform X11

Conserved Domains (3) summary

cd11972
Location:426 → 486

SH3_Abi2; Src homology 3 domain of Abl Interactor 2

PHA03247
Location:215 → 351

PHA03247; large tegument protein UL36; Provisional

pfam07815
Location:93 → 163

Abi_HHR; Abl-interactor HHR
XM_006496084.4 → XP_006496147.1 abl interactor 2 isoform X19

UniProtKB/TrEMBL

A0A087WRS3

Related

ENSMUSP00000140750.2, ENSMUST00000188594.7

Conserved Domains (3) summary

cd11972
Location:397 → 457

SH3_Abi2; Src homology 3 domain of Abl Interactor 2

PHA03247
Location:215 → 342

PHA03247; large tegument protein UL36; Provisional

pfam07815
Location:93 → 163

Abi_HHR; Abl-interactor HHR
XM_030255013.1 → XP_030110873.1 abl interactor 2 isoform X12

Conserved Domains (3) summary

cd11972
Location:425 → 485

SH3_Abi2; Src homology 3 domain of Abl Interactor 2

PHA03247
Location:214 → 350

PHA03247; large tegument protein UL36; Provisional

pfam07815
Location:93 → 163

Abi_HHR; Abl-interactor HHR
XM_036165790.1 → XP_036021683.1 abl interactor 2 isoform X20

Conserved Domains (3) summary

cd11972
Location:396 → 456

SH3_Abi2; Src homology 3 domain of Abl Interactor 2

PHA03247
Location:214 → 341

PHA03247; large tegument protein UL36; Provisional

pfam07815
Location:93 → 156

Abi_HHR; Abl-interactor HHR
XM_036165801.1 → XP_036021694.1 abl interactor 2 isoform X26

Conserved Domains (2) summary

cd11972
Location:364 → 424

SH3_Abi2; Src homology 3 domain of Abl Interactor 2

pfam07815
Location:93 → 156

Abi_HHR; Abl-interactor HHR
XM_017321247.2 → XP_017176736.1 abl interactor 2 isoform X18

Conserved Domains (3) summary

cd11972
Location:402 → 462

SH3_Abi2; Src homology 3 domain of Abl Interactor 2

PHA03247
Location:220 → 347

PHA03247; large tegument protein UL36; Provisional

pfam07815
Location:93 → 169

Abi_HHR; Abl-interactor HHR