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    hbs1l HBS1-like translational GTPase [ Danio rerio (zebrafish) ]

    Gene ID: 324267, updated on 11-Apr-2024

    Summary

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    Official Symbol
    hbs1lprovided by ZNC
    Official Full Name
    HBS1-like translational GTPaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2987
    See related
    Ensembl:ENSDARG00000036778 AllianceGenome:ZFIN:ZDB-GENE-030131-2987
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55400; wu:fc23c07
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in translation. Human ortholog(s) of this gene implicated in beta thalassemia. Orthologous to human HBS1L (HBS1 like translational GTPase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 23
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (31767312..31810246, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (31840781..31883710, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene serum/glucocorticoid regulated kinase 1 Neighboring gene aldehyde dehydrogenase 8 family, member A1 Neighboring gene v-myb avian myeloblastosis viral oncogene homolog Neighboring gene uncharacterized LOC103909697

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition. Cabrera-Quio LE, et al. PLoS Genet, 2021 Feb. PMID 33600438, Free PMC Article
    2. GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish. Jiménez-Amilburu V, et al. J Endocrinol, 2015 Jan. PMID 25326603
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    HBS1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308548.1 → NP_001295477.1  HBS1-like protein

      Status: VALIDATED

      Source sequence(s)
      BX927365, CT587014, EB894746
      UniProtKB/TrEMBL
      A0A8M1P708, F1Q5Z6
      Related
      ENSDARP00000118572.1, ENSDART00000139076.3
      Conserved Domains (5) summary
      cd01883
      Location:260 → 479
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:254 → 682
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam08938
      Location:78 → 130
      HBS1_N; HBS1 N-terminus
      cd16267
      Location:485 → 568
      HBS1-like_II; Domain II of Hbs1-like proteins
      cd04093
      Location:572 → 680
      HBS1_C_III; C-terminal domain of Hsp70 subfamily B suppressor 1 (HBS1)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      31767312..31810246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353518.2 → XP_017209007.1  HBS1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8M6YV72

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395160.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      161770..204792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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