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    Ankrd16 ankyrin repeat domain 16 [ Mus musculus (house mouse) ]

    Gene ID: 320816, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ankrd16provided by MGI
    Official Full Name
    ankyrin repeat domain 16provided by MGI
    Primary source
    MGI:MGI:2444796
    See related
    Ensembl:ENSMUSG00000047909 AllianceGenome:MGI:2444796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810455F06Rik; D430029B21Rik
    Summary
    Involved in tRNA modification. Located in cytoplasm and nucleus. Orthologous to human ANKRD16 (ankyrin repeat domain 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 16.4), CNS E14 (RPKM 15.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd16 in Genome Data Viewer
    Location:
    2 A1; 2 9.05 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (11781902..11795138)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (11777753..11790327)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene interleukin 15 receptor, alpha chain Neighboring gene predicted gene, 46731 Neighboring gene F-box DNA helicase 1 Neighboring gene STARR-positive B cell enhancer ABC_E804 Neighboring gene STARR-seq mESC enhancer starr_03678 Neighboring gene STARR-seq mESC enhancer starr_03679 Neighboring gene predicted gene, 34768 Neighboring gene ankyrin repeat domain-containing protein 20A12 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase. Vo MN, et al. Nature, 2018 May. PMID 29769718, Free PMC Article
    2. Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs. Wang Q, et al. BMC Genomics, 2011 Apr 21. PMID 21510876, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363082.1 → NP_001350011.1  ankyrin repeat domain-containing protein 16 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL845548
      Conserved Domains (3) summary
      sd00045
      Location:59 → 91
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1 → 46
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:30 → 125
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_177268.4 → NP_796242.2  ankyrin repeat domain-containing protein 16 isoform 1

      See identical proteins and their annotated locations for NP_796242.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL845548
      Consensus CDS
      CCDS50502.1
      UniProtKB/Swiss-Prot
      A2AS55, Q8BH84
      Related
      ENSMUSP00000052056.6, ENSMUST00000056108.12
      Conserved Domains (3) summary
      cd00204
      Location:37 → 157
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:41 → 134
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:37 → 68
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_156440.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845548

    2. NR_156441.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845548

    3. NR_156442.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845548

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      11781902..11795138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238978.3 → XP_011237280.1  ankyrin repeat domain-containing protein 16 isoform X1

      Conserved Domains (3) summary
      COG0666
      Location:33 → 158
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:37 → 68
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:175 → 304
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_036162312.1 → XP_036018205.1  ankyrin repeat domain-containing protein 16 isoform X2

      UniProtKB/TrEMBL
      Q3USW0
      Conserved Domains (2) summary
      COG0666
      Location:33 → 158
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:37 → 68
      ANK; ANK repeat [structural motif]

    3. XM_030251769.2 → XP_030107629.1  ankyrin repeat domain-containing protein 16 isoform X4

      Conserved Domains (3) summary
      sd00045
      Location:59 → 91
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1 → 46
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:30 → 125
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_036162313.1 → XP_036018206.1  ankyrin repeat domain-containing protein 16 isoform X3

      Conserved Domains (3) summary
      sd00045
      Location:69 → 101
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:9 → 56
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:40 → 135
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_036162314.1 → XP_036018207.1  ankyrin repeat domain-containing protein 16 isoform X4

      Conserved Domains (3) summary
      sd00045
      Location:59 → 91
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1 → 46
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:30 → 125
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. XR_004940636.1 RNA Sequence

    2. XR_004940638.1 RNA Sequence

    3. XR_004940632.1 RNA Sequence

    4. XR_004940629.1 RNA Sequence

    5. XR_004940631.1 RNA Sequence

    6. XR_004940639.1 RNA Sequence

    7. XR_004940637.1 RNA Sequence

    8. XR_004940630.1 RNA Sequence

    9. XR_004940640.1 RNA Sequence

    10. XR_004940645.1 RNA Sequence

    11. XR_004940644.1 RNA Sequence

    12. XR_004940643.1 RNA Sequence

    13. XR_004940633.1 RNA Sequence

    14. XR_004940641.1 RNA Sequence

    15. XR_003953500.2 RNA Sequence

    16. XR_004940635.1 RNA Sequence

    17. XR_373941.3 RNA Sequence

    18. XR_004940634.1 RNA Sequence

    19. XR_004940642.1 RNA Sequence

    20. XR_003953498.2 RNA Sequence

    21. XR_004940627.1 RNA Sequence

    22. XR_004940628.1 RNA Sequence

    23. XR_003953497.2 RNA Sequence

    24. XR_373938.2 RNA Sequence

    25. XR_373937.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AS55.1 GenPept UniProtKB/Swiss-Prot:A2AS55

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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