Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bloc1s6provided by RGD
Official Full Name: biogenesis of lysosomal organelles complex 1 subunit 6provided by RGD
Primary source: RGD:1310208
See related: Ensembl:ENSRNOG00000037160 AllianceGenome:RGD:1310208
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pldn
Summary: Predicted to enable actin filament binding activity and protein homodimerization activity. Predicted to be involved in several processes, including cellular amino acid metabolic process; establishment of vesicle localization; and limbic system development. Predicted to act upstream of or within several processes, including melanocyte differentiation; positive regulation of natural killer cell activation; and secretion of lysosomal enzymes. Predicted to be located in ciliary basal body and endosome. Predicted to be part of BLOC-1 complex. Predicted to be active in transport vesicle. Predicted to be extrinsic component of membrane. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 9. Orthologous to human BLOC1S6 (biogenesis of lysosomal organelles complex 1 subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 115.4), Adrenal (RPKM 91.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (130269979..130280109)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (109816397..109826528)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (114869478..114880218)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ATP metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenosine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amino acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in anterograde axonal transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde axonal transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in anterograde synaptic vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde synaptic vesicle transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bradykinin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within circadian sleep/wake cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dentate gyrus development	ISO Inferred from Sequence Orthology more info
involved_in endosome to melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in endosome to melanosome transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within endothelium development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glutamate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glutamine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hypothalamus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular nitric oxide homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within melanocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in melanosome transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within membrane fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pigment cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pigment cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein targeting	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory system process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to acetylcholine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within secretion of lysosomal enzymes	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BLOC-1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BLOC-1 complex	ISO Inferred from Sequence Orthology more info
part_of BLOC-1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
part_of SNARE complex	ISS Inferred from Sequence or Structural Similarity more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
is_active_in contractile ring	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane-bounded organelle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microvesicle	ISO Inferred from Sequence Orthology more info
is_active_in ruffle	ISO Inferred from Sequence Orthology more info
is_active_in stress fiber	ISO Inferred from Sequence Orthology more info
is_active_in transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle	ISO Inferred from Sequence Orthology more info
located_in transport vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: biogenesis of lysosome-related organelles complex 1 subunit 6

Names: BLOC-1 subunit 6; biogenesis of lysosomal organelles complex-1, subunit 6, pallidin; pallid protein homolog; pallidin homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025714.1 → NP_001020885.1 biogenesis of lysosome-related organelles complex 1 subunit 6

See identical proteins and their annotated locations for NP_001020885.1

Status: PROVISIONAL

Source sequence(s)

BC097469

UniProtKB/Swiss-Prot

Q4V8A6

Related

ENSRNOT00000056083.4

Conserved Domains (1) summary

pfam14712
Location:55 → 140

Snapin_Pallidin; Snapin/Pallidin