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    RpS6 Ribosomal protein S6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31700, updated on 27-Mar-2024

    Summary

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    Official Symbol
    RpS6provided by FlyBase
    Official Full Name
    Ribosomal protein S6provided by FlyBase
    Primary source
    FLYBASE:FBgn0261592
    Locus tag
    Dmel_CG10944
    See related
    AllianceGenome:FB:FBgn0261592
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    (Rp)S6; air8; air[8]; anon-WO02059370.61; CG10944; Dmel\CG10944; DS6; hen; l(1)air8; l(1)air[8]; l(1)hen; M(1)7BC; M(1)7C; pp30; Rp S6; rps6; rpS6; Rps6; RPS6; S6; S6e
    Summary
    A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Orthologous to human RPS6 (ribosomal protein S6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RpS6 in Genome Data Viewer
    Location:
    7C2-7C2; 1-21 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7899624..7901331, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7793657..7795364, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene p115 Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene by S6 Neighboring gene defective proboscis extension response 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nucleotide sequence of a cloned cDNA encoding ribosomal protein S6 from Drosophila melanogaster. Spencer TA, et al. Biochim Biophys Acta, 1993 Mar 20. PMID 8448211
    2. Mitogenesis and protein synthesis: a role for ribosomal protein S6 phosphorylation? Stewart MJ, et al. Bioessays, 1994 Nov. PMID 7840758
    3. Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system. Watson KL, et al. Proc Natl Acad Sci U S A, 1992 Dec 1. PMID 1454811, Free PMC Article
    4. An encore for ribosome biogenesis in the control of cell proliferation. Thomas G. Nat Cell Biol, 2000 May. PMID 10806485
    5. Identification of insulin-induced sites of ribosomal protein S6 phosphorylation in Drosophila melanogaster. Radimerski T, et al. Biochemistry, 2000 May 16. PMID 10801327

    See all (132) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of ribosome HDA PubMed 
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosolic ribosome HDA PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S6
    Names
    CG10944-PA
    CG10944-PB
    RpS6-PA
    RpS6-PB
    S6 ribosomal protein
    hemocytes enlarged
    lethal(1)aberrant immune response[8]
    lethal-(1)-haemocytes enlarged
    lethal-aberrant-immune-response-8
    minute
    minute (1) 7BC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7899624..7901331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078518.3 → NP_511073.1  ribosomal protein S6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511073.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29327, Q94993, Q9W3N4
      UniProtKB/TrEMBL
      D2NUH9, H1ZYF1
      Related
      FBpp0071087
      Conserved Domains (1) summary
      cl00931
      Location:1 → 222
      Ribosomal_S6e; Ribosomal protein S6e

    2. NM_167136.2 → NP_727213.1  ribosomal protein S6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727213.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TP9
      Related
      FBpp0071088
      Conserved Domains (1) summary
      cl00931
      Location:1 → 191
      Ribosomal_S6e; Ribosomal protein S6e
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    4V6W_AG.1
    P29327.1 P29327
    Q95TP9 Q95TP9

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