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    Agbl1 AGBL carboxypeptidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308724, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Agbl1provided by RGD
    Official Full Name
    AGBL carboxypeptidase 1provided by RGD
    Primary source
    RGD:1560280
    See related
    Ensembl:ENSRNOG00000022610 AllianceGenome:RGD:1560280
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560280
    Summary
    Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Predicted to be involved in C-terminal protein deglutamylation and protein side chain deglutamylation. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy. Orthologous to human AGBL1 (AGBL carboxypeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 135.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q31
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (139453667..140360473)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (130043914..130950739)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (137798862..138711126)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC108349597 Neighboring gene high mobility group protein B1-like Neighboring gene vomeronasal 1 receptor pseudogene 67 Neighboring gene uncharacterized LOC102553800

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids. Tort O, et al. Mol Biol Cell, 2014 Oct 1. PMID 25103237, Free PMC Article
    2. A family of protein-deglutamylating enzymes associated with neurodegeneration. Rogowski K, et al. Cell, 2010 Nov 12. PMID 21074048
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in C-terminal protein deglutamylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein side chain deglutamylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic carboxypeptidase 4
    Names
    ATP/GTP binding protein-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      139453667..140360473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101030.2 → XP_038956958.1  cytosolic carboxypeptidase 4 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JV75
      Related
      ENSRNOP00000069378.2
      Conserved Domains (2) summary
      pfam18027
      Location:595 → 729
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
      cl11393
      Location:753 → 974
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    2. XM_063280964.1 → XP_063137034.1  cytosolic carboxypeptidase 4 isoform X2

    3. XM_008759580.4 → XP_008757802.2  cytosolic carboxypeptidase 4 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWW4
      Related
      ENSRNOP00000076044.1

    4. XM_039101031.2 → XP_038956959.1  cytosolic carboxypeptidase 4 isoform X4

      Conserved Domains (2) summary
      pfam18027
      Location:488 → 622
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
      cl11393
      Location:646 → 911
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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