robo1 roundabout, axon guidance receptor, homolog 1 (Drosophila) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: robo1provided by ZNC
Official Full Name: roundabout, axon guidance receptor, homolog 1 (Drosophila)provided by ZNC
Primary source: ZFIN:ZDB-GENE-000209-3
See related: Ensembl:ENSDARG00000026784 AllianceGenome:ZFIN:ZDB-GENE-000209-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: SAG4A; t2gtl4a
Summary: Predicted to enable axon guidance receptor activity. Acts upstream of or within axon guidance and endocardial progenitor cell migration to the midline involved in heart field formation. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in basal plate midbrain region; epidermis; nervous system; pectoral fin; and pharyngeal arch. Orthologous to human ROBO1 (roundabout guidance receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (39277653..39819928, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (39431106..39972889, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results demonstrate a key role for Robo-Slit signaling in vertebrate longitudinal axon guidance; Robo1 and Robo3 restricted the extent of defasciculation of the tract of the postoptic commissure.
Title: Robo-Slit interactions regulate longitudinal axon pathfinding in the embryonic vertebrate brain.

Submit: New GeneRIF Correction

General gene information

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Markers

G39006 (e-PCR)
- UniSTS:71509

fb77b08.x1 (e-PCR)
- UniSTS:187529

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables axon guidance receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Roundabout signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon midline choice point recognition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocardial progenitor cell migration to the midline involved in heart field formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: roundabout homolog 1

Names: roundabout (axon guidance receptor, Drosophila) homolog 1; tol2 transposon-derived gene trap locus 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001309824.2 → NP_001296753.1 roundabout homolog 1 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

CU694228, CU695212, CU855934, FP015879

UniProtKB/TrEMBL

A0A8M1P7C2

Conserved Domains (7) summary

cd05725
Location:241 → 309

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:29 → 128

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

smart00410
Location:423 → 504

IG_like; Immunoglobulin like

cd00063
Location:523 → 614

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:224 → 309

I-set; Immunoglobulin I-set domain

pfam00041
Location:741 → 827

fn3; Fibronectin type III domain

cl11960
Location:327 → 416

Ig; Immunoglobulin domain
NM_001365166.1 → NP_001352095.1 roundabout homolog 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

CR626875, CU694228, CU695212, CU855934, FP015879

UniProtKB/TrEMBL

A0A8M6Z2A1

Conserved Domains (7) summary

cd05725
Location:282 → 349

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:70 → 169

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:567 → 658

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:785 → 871

fn3; Fibronectin type III domain

pfam13927
Location:460 → 534

Ig_3; Immunoglobulin domain

cl11960
Location:371 → 460

Ig; Immunoglobulin domain

cl28033
Location:1477 → 1639

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
NM_001365167.1 → NP_001352096.1 roundabout homolog 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

CR626875, CU694228, CU695212, CU855934, FP015879

Conserved Domains (7) summary

cd05725
Location:282 → 350

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:70 → 169

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:564 → 655

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:782 → 868

fn3; Fibronectin type III domain

pfam13927
Location:457 → 531

Ig_3; Immunoglobulin domain

cl11960
Location:368 → 457

Ig; Immunoglobulin domain

cl28033
Location:1473 → 1635

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

39277653..39819928 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017359208.2 → XP_017214697.1 roundabout homolog 1 isoform X5

Related

ENSDARP00000087907.5, ENSDART00000097134.6

Conserved Domains (7) summary

cd05725
Location:282 → 349

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:70 → 169

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:567 → 658

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:785 → 871

fn3; Fibronectin type III domain

pfam13927
Location:460 → 534

Ig_3; Immunoglobulin domain

cl11960
Location:371 → 460

Ig; Immunoglobulin domain

cl28033
Location:1477 → 1639

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_021481331.1 → XP_021337006.1 roundabout homolog 1 isoform X6

UniProtKB/TrEMBL

A0A8M9QL91

Conserved Domains (7) summary

cd05725
Location:250 → 317

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:38 → 137

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:535 → 626

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:753 → 839

fn3; Fibronectin type III domain

pfam13927
Location:428 → 502

Ig_3; Immunoglobulin domain

cl11960
Location:339 → 428

Ig; Immunoglobulin domain

cl28033
Location:1445 → 1607

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_017359207.2 → XP_017214696.2 roundabout homolog 1 isoform X3

UniProtKB/TrEMBL

A0A8M6Z9Z2

Conserved Domains (7) summary

cd05725
Location:271 → 339

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:59 → 158

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:553 → 644

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:771 → 857

fn3; Fibronectin type III domain

pfam13927
Location:446 → 520

Ig_3; Immunoglobulin domain

cl11960
Location:357 → 446

Ig; Immunoglobulin domain

cl28033
Location:1462 → 1624

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_017359206.2 → XP_017214695.2 roundabout homolog 1 isoform X2

UniProtKB/TrEMBL

A0A8M6Z4B7

Conserved Domains (7) summary

cd05725
Location:271 → 339

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:59 → 158

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:553 → 644

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:771 → 857

fn3; Fibronectin type III domain

pfam13927
Location:446 → 520

Ig_3; Immunoglobulin domain

cl11960
Location:357 → 446

Ig; Immunoglobulin domain

cl28033
Location:1463 → 1625

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_021481332.1 → XP_021337007.1 roundabout homolog 1 isoform X10

UniProtKB/TrEMBL

A0A8M9Q051

Conserved Domains (6) summary

cd05725
Location:271 → 338

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:59 → 158

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:556 → 647

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:774 → 860

fn3; Fibronectin type III domain

pfam13927
Location:449 → 523

Ig_3; Immunoglobulin domain

cl11960
Location:360 → 449

Ig; Immunoglobulin domain
XM_017359205.2 → XP_017214694.2 roundabout homolog 1 isoform X1

UniProtKB/TrEMBL

A0A8M6Z2U1

Conserved Domains (7) summary

cd05725
Location:271 → 338

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:59 → 158

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:556 → 647

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:774 → 860

fn3; Fibronectin type III domain

pfam13927
Location:449 → 523

Ig_3; Immunoglobulin domain

cl11960
Location:360 → 449

Ig; Immunoglobulin domain

cl28033
Location:1465 → 1627

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_017359212.2 → XP_017214701.2 roundabout homolog 1 isoform X4

UniProtKB/TrEMBL

A0A8M6Z9Z4

Conserved Domains (7) summary

cd05725
Location:296 → 363

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:84 → 183

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:581 → 672

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:799 → 885

fn3; Fibronectin type III domain

pfam13927
Location:474 → 548

Ig_3; Immunoglobulin domain

cl11960
Location:385 → 474

Ig; Immunoglobulin domain

cl28033
Location:1491 → 1653

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_017359211.2 → XP_017214700.1 roundabout homolog 1 isoform X9

UniProtKB/TrEMBL

A0A8M6Z4C2
XM_017359209.2 → XP_017214698.1 roundabout homolog 1 isoform X7

UniProtKB/TrEMBL

A0A8M6Z9L1
XM_017359210.2 → XP_017214699.1 roundabout homolog 1 isoform X8

UniProtKB/TrEMBL

A0A8M6Z2U5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_131481.1: Suppressed sequence

Description

NM_131481.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.