kif23 kinesin family member 23 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kif23provided by ZNC
Official Full Name: kinesin family member 23provided by ZNC
Primary source: ZFIN:ZDB-GENE-991019-4
See related: Ensembl:ENSDARG00000014943 AllianceGenome:ZFIN:ZDB-GENE-991019-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb738; knsl5; mklp1; zMKLP1; wu:fi30e02; wu:fi39f08
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within cytoskeleton-dependent cytokinesis; embryonic cleavage; and vesicle transport along microtubule. Located in several cellular components, including cleavage furrow; microtubule; and nucleus. Is expressed in proliferative region. Orthologous to human KIF23 (kinesin family member 23). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (20436274..20458426, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (20447208..20469362, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fi39f08.x1 (e-PCR)
- UniSTS:197452

AW174941 (e-PCR)
- UniSTS:205796

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cleavage furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic cleavage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule-based movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle midzone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kinesin-like protein KIF23

Names: kinesin-like 5; mitotic kinesin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131355.1 → NP_571430.1 kinesin-like protein KIF23

See identical proteins and their annotated locations for NP_571430.1

Status: PROVISIONAL

Source sequence(s)

AF139990

UniProtKB/TrEMBL

A0A0R4IKS5, A0A8N7UZJ3, Q9PUU5

Related

ENSDARP00000026695.8, ENSDART00000012241.10

Conserved Domains (6) summary

cd01368
Location:24 → 434

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam00225
Location:31 → 436

Kinesin; Kinesin motor domain

pfam08614
Location:453 → 633

ATG16; Autophagy protein 16 (ATG16)

pfam16046
Location:535 → 596

FAM76; FAM76 protein

pfam16540
Location:710 → 810

MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

cl23720
Location:505 → 657

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

20436274..20458426 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467586.1 → XP_021323261.1 kinesin-like protein KIF23 isoform X1

UniProtKB/TrEMBL

A0A8M9PLX5

Conserved Domains (3) summary

cd01368
Location:24 → 449

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam16540
Location:825 → 928

MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

cl25732
Location:526 → 699

SMC_N; RecF/RecN/SMC N terminal domain
XM_021467587.1 → XP_021323262.1 kinesin-like protein KIF23 isoform X2

UniProtKB/TrEMBL

A0A8M9P0Y6

Conserved Domains (3) summary

cd01368
Location:24 → 434

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam16540
Location:810 → 913

MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

cl25732
Location:511 → 684

SMC_N; RecF/RecN/SMC N terminal domain
XM_009293529.3 → XP_009291804.1 kinesin-like protein KIF23 isoform X3

UniProtKB/TrEMBL

A0A286Y967, A0A8M3AUT8

Related

ENSDARP00000143716.1, ENSDART00000177125.2

Conserved Domains (6) summary

cd01368
Location:24 → 449

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam00225
Location:31 → 451

Kinesin; Kinesin motor domain

pfam08614
Location:468 → 648

ATG16; Autophagy protein 16 (ATG16)

pfam16046
Location:550 → 611

FAM76; FAM76 protein

pfam16540
Location:725 → 825

MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

cl23720
Location:520 → 672

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)