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    Cdc42ep4 CDC42 effector protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303653, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Cdc42ep4provided by RGD
    Official Full Name
    CDC42 effector protein 4provided by RGD
    Primary source
    RGD:1311567
    See related
    Ensembl:ENSRNOG00000028946 AllianceGenome:RGD:1311567
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in Rho protein signal transduction; positive regulation of cellular component biogenesis; and regulation of cell shape. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in adherens junction; cytoskeleton; and phagocytic vesicle. Predicted to be active in cytoplasm; cytoskeleton; and plasma membrane. Orthologous to human CDC42EP4 (CDC42 effector protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 133.8), Adrenal (RPKM 109.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q32.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (99271750..99298551, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (98772613..98797924, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (102244680..102269272, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene mitochondrial nucleoid associated protein 1 Neighboring gene cleavage and polyadenylation specific factor 4-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene uncharacterized LOC102547853 Neighboring gene sidekick cell adhesion molecule 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. Hirsch DS, et al. J Biol Chem, 2001 Jan 12. PMID 11035016
    2. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Joberty G, et al. Mol Cell Biol, 1999 Oct. PMID 10490598, Free PMC Article
    3. The phagosomal proteome in interferon-gamma-activated macrophages. Trost M, et al. Immunity, 2009 Jan 16. PMID 19144319
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of pseudopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of pseudopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cdc42 effector protein 4
    Names
    CDC42 effector protein (Rho GTPase binding) 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107063.3 → NP_001100533.1  cdc42 effector protein 4

      See identical proteins and their annotated locations for NP_001100533.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5Y758, B1WC33
      Conserved Domains (2) summary
      pfam00786
      Location:26 → 83
      PBD; P21-Rho-binding domain
      pfam14957
      Location:110 → 219
      BORG_CEP; Cdc42 effector

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      99271750..99298551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086182.2 → XP_038942110.1  cdc42 effector protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y758, B1WC33
      Related
      ENSRNOP00000045828.3
      Conserved Domains (2) summary
      pfam00786
      Location:26 → 83
      PBD; P21-Rho-binding domain
      pfam14957
      Location:110 → 219
      BORG_CEP; Cdc42 effector

    2. XM_006247689.5 → XP_006247751.1  cdc42 effector protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006247751.1

      UniProtKB/TrEMBL
      A0A8I5Y758, B1WC33
      Related
      ENSRNOP00000078041.1
      Conserved Domains (2) summary
      pfam00786
      Location:26 → 83
      PBD; P21-Rho-binding domain
      pfam14957
      Location:110 → 219
      BORG_CEP; Cdc42 effector

    3. XM_006247688.4 → XP_006247750.1  cdc42 effector protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006247750.1

      UniProtKB/TrEMBL
      A0A8I5Y758, B1WC33
      Related
      ENSRNOP00000090992.1
      Conserved Domains (2) summary
      pfam00786
      Location:26 → 83
      PBD; P21-Rho-binding domain
      pfam14957
      Location:110 → 219
      BORG_CEP; Cdc42 effector

    4. XM_039086181.2 → XP_038942109.1  cdc42 effector protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y758, B1WC33
      Conserved Domains (2) summary
      pfam00786
      Location:26 → 83
      PBD; P21-Rho-binding domain
      pfam14957
      Location:110 → 219
      BORG_CEP; Cdc42 effector

    5. XM_006247690.5 → XP_006247752.1  cdc42 effector protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006247752.1

      UniProtKB/TrEMBL
      A0A8I5Y758, B1WC33
      Related
      ENSRNOP00000077095.1
      Conserved Domains (2) summary
      pfam00786
      Location:26 → 83
      PBD; P21-Rho-binding domain
      pfam14957
      Location:110 → 219
      BORG_CEP; Cdc42 effector
    Nucleotide Protein Strain
    Heading Accession and Version

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